Clinical Validation of a Coronary Surgery Technique That Minimizes Aortic Manipulation

Ann Thorac Surg. 2019 Apr;107(4):1166-1173. doi: 10.1016/j.athoracsur.2018.09.063. Epub 2018 Nov 13.

Abstract

Background: To minimize aortic manipulation and maximize use of arterial conduits are aims of modern coronary surgery.

Methods: From March 2012 to October 2016, 890 consecutive patients with multivessel coronary disease underwent isolated coronary operations using both internal thoracic arteries (ITAs). In 205 (23%; mean age, 67.6 ± 9.2 years), the right ITA was proximally transected and used as a free graft, while its in situ stump was elongated with a saphenous vein graft. The new arteriovenous I conduit was directed to the inferolateral cardiac wall. Operative data and early outcomes of these patients (I group) were compared with the remaining 685 patients (control [C] group). Early and late outcomes were also compared in 184 pairs identified with propensity score matching.

Results: Between the I and C groups there was no significant difference in expected operative risk (European System for Cardiac Operative Risk Evaluation II, p = 0.28), although diseased ascending aorta (p < 0.0001) and critical preoperative state (p = 0.027) were more frequent in the I group. Despite a higher number of coronary anastomoses (mean, 4 ± 0.9 vs 3.7 ± 1, p < 0.0001), cardiopulmonary bypass time was shorter in the I group both in overall (86.7 ± 23.7 vs 105.7 ± 34.2 minutes, p < 0.0001) and matched series (86.8 ± 24.1 vs 108.8 ± 31.9 minutes, p < 0.0001). In-hospital mortality (1% vs 1.9%, p = 0.54) and the rates of postoperative complications were similar. During the follow-up period, no intergroup difference was found in matched patients in the nonparametric estimates of freedom from all-cause death (p = 0.39) and major adverse cardiac and cerebrovascular events (p = 0.44).

Conclusions: Surgery using this arteriovenous I conduit is safe, minimizes aortic manipulation, shortens cardiopulmonary bypass time, and aids complete revascularization.

Publication types

  • Comparative Study
  • Validation Study

MeSH terms

  • Aged
  • Aged, 80 and over
  • Anastomotic Leak / prevention & control*
  • Case-Control Studies
  • Coronary Angiography / methods
  • Coronary Artery Bypass / methods*
  • Coronary Stenosis / diagnostic imaging
  • Coronary Stenosis / mortality
  • Coronary Stenosis / surgery*
  • Female
  • Follow-Up Studies
  • Hospital Mortality*
  • Humans
  • Internal Mammary-Coronary Artery Anastomosis / methods*
  • Italy
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Minimally Invasive Surgical Procedures / methods
  • Retrospective Studies
  • Risk Assessment
  • Severity of Illness Index
  • Statistics, Nonparametric
  • Survival Analysis
  • Time Factors
  • Treatment Outcome
  • Vascular Patency / physiology