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Can J Physiol Pharmacol. 2018 Nov 16. doi: 10.1139/cjpp-2018-0490. [Epub ahead of print]

Oxidized Lipids: Not just another brick in the wall.

Author information

1
St. Boniface General Hospital, Institute of Cardiovascualr Sciences, Winnipeg, Manitoba, Canada ; AStamenkovic@sbrc.ca.
2
Division of Stroke and Vascular Disease , St. Boniface Hospital Research Centre , 351 Tache Avenue , Winnipeg, Manitoba, Canada , R2H 2A6 ; gpierce@sbrc.ca.
3
St. Boniface General Hospital, Interventional Cardiology , Rm Y3508 Bergen Cardiac Care Centre Division of Cardiology , 409 Tache Avenue , Winnipeg, Manitoba, Canada , R2H 2A6 ; aravandi@sbgh.mb.ca.

Abstract

Over the past decade there has been intense investigation in trying to understand the pathological role that oxidized phospholipids play in cardiovascular disease. Phospholipids are targets for oxidation, particularly during conditions of excess free radical generation. Once oxidized, they acquire novel roles uncharacteristic of their precursors. Oxidized phosphatidylcholines have an important role in multiple physiological and pathophysiological conditions including atherosclerosis, neurodegenerative diseases, lung disease, inflammation, and chronic alcohol consumption. Circulating oxidized phosphatidylcholine may also serve as a clinical biomarker. The focus of this review, therefore, will be to summarize existing evidence that oxidized phosphatidylcholine molecules play an important role in cardiovascular pathology.

PMID:
30444647
DOI:
10.1139/cjpp-2018-0490

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