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Magn Reson Med. 2019 May;81(5):3314-3329. doi: 10.1002/mrm.27613. Epub 2018 Nov 16.

Motion-robust diffusion compartment imaging using simultaneous multi-slice acquisition.

Author information

1
Department of Radiology, Boston Children's Hospital, Boston, Massachusetts.
2
Harvard Medical School, Boston, Massachusetts.
3
Icahn School of Medicine at Mount Sinai New York, New York.
4
Department of Neurology, Boston Children's Hospital, Boston, Massachusetts.

Abstract

PURPOSE:

To achieve motion-robust diffusion compartment imaging (DCI) in near continuously moving subjects based on simultaneous multi-slice, diffusion-weighted brain MRI.

METHODS:

Simultaneous multi-slice (SMS) acquisition enables fast and dense sampling of k- and q-space. We propose to achieve motion-robust DCI via slice-level motion correction by exploiting the rigid coupling between simultaneously acquired slices. This coupling provides 3D coverage of the anatomy that substantially constraints the slice-to-volume alignment problem. This is incorporated into an explicit model of motion dynamics that handles continuous and large subject motion in robust DCI reconstruction.

RESULTS:

We applied the proposed technique, called Motion Tracking based on Simultanous Multislice Registration (MT-SMR) to multi b-value SMS diffusion-weighted brain MRI of healthy volunteers and motion-corrupted scans of 20 pediatric subjects. Quantitative and qualitative evaluation based on fractional anisotropy in unidirectional fiber regions, and DCI in crossing-fiber regions show robust reconstruction in the presence of motion.

CONCLUSION:

The proposed approach has the potential to extend routine use of SMS DCI in very challenging populations, such as young children, newborns, and non-cooperative patients.

KEYWORDS:

Diffusion-compartment imaging; diffusion-weighted MRI; image-based navigation; intra-volume motion; motion tracking; motion-robust; simultaneous multi-slice; slice registration

PMID:
30443929
PMCID:
PMC6414287
[Available on 2020-05-01]
DOI:
10.1002/mrm.27613

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