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Int J Med Sci. 2018 Oct 20;15(13):1517-1521. doi: 10.7150/ijms.28337. eCollection 2018.

Ethanol Extract from Brucea Javanica Seed Inhibits Angiogenesis Mediated by Platelet Derived Growth Factor Receptor-beta.

Wang X1,2, Li Y3, Mou Y1,4, Yue Z1, Zhang H1, Li R1, Sun H3.

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Key Laboratory of Pathobiology, Ministry of Education, Norman Bethune College of Medicine, Jilin University, Changchun, China.
Current address: Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, Tianjin, China.
People's Hospital of Jilin Province and Changchun University of Chinese Medicine, Changchun, P.R. China.
Second Hospital of Jilin University, Changchun, China.


The present study aimed to investigate the effects of ethanol extract from Brucea javanicaseed (EEBJS) on the angiogenesis of human umbilical vein endothelial cells (HUVECs) and the possible molecular signal involved. Firstly, a Matrigel-based in vitro angiogenesis assay demonstrated that EEBJS inhibited the angiogenesis of HUVECs in a dose-dependent manner. Then by using porcine aortic endothelial cells which stably express human PDGFR-beta, we found that the inhibition of angiogenesis was mediated by PDGFR-beta. Taken together, we conclude that EEBJS inhibited the angiogenesis function of the vascular endothelial cells mediated by PDGFR-beta, and postulate that it might contribute to the therapeutic effects of EEBJS on malignant tumors.


Angiogenesis; Ethanol Extract from Brucea javanica Seed; Human Umbilical Vein Endothelial Cells; Malignant Tumors; Platelet Derived Growth Factor Receptor

Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

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