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Int J Med Sci. 2018 Sep 7;15(13):1443-1448. doi: 10.7150/ijms.27341. eCollection 2018.

Biology of MiR-17-92 Cluster and Its Progress in Lung Cancer.

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1
Lab for Noncoding RNA & Cancer, School of Life Sciences Shanghai University, Shanghai 200444.

Abstract

MicroRNAs, a class of short endogenous RNAs, acting as post-transcriptional regulators of gene expression, mostly silence gene expression via binding imperfectly matched sequences in the 3'UTR of target mRNA. MiR-17-92, a highly conserved gene cluster, has 6 members including miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1 and miR-92a. The miR-17-92 cluster, regarded as oncogene, is overexpressed in human cancers. Lung cancer is the leading cause of death all over the world. The molecular mechanism of lung cancer has been partly known at the levels of genes and proteins in last decade. However, new prognosis biomarkers and more target drugs should be developed in future. Therefore, noncoding RNAs, especially miRNAs, make them as new potentially clinical biomarkers for diagnosis and prognosis. In this review, we focus the current progress of miR-17-92 cluster in lung cancer.

KEYWORDS:

lung cancer; miR-17-92 cluster; microRNAs; oncogene; tumorigenesis

Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

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