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Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:1608-1611. doi: 10.1109/EMBC.2018.8512653.

A Wireless Optoelectronic Neuroscience Platform for Chronic Fluorescence Sensing in Freely Behaving Rodents.

Abstract

We present a new head mountable wireless fiber biophotometry microsystem conceived to detect fluorescent signal fluctuations correlated with neuronal activity. The proposed system incorporates all aspects of a conventional tethered fiber-based biophotometry system encompassed into a wireless microsystem. The interface includes an LED as excitation light source, a custom designed CMOS biosensor, a multimode fiber, a microcontroller (MCU), and a wireless data transceiver enclosed within a 3D-printed, small and light weight, plastic housing. Precisely, the system incorporates a new optoelectronic biosensor merging two individual building blocks, namely a low-noise sensing front-end and $\mathrm {a}2 ^{nd}$ order continuous-time $\Sigma \Delta $ modulator (CTSDM), into a single module for enabling high-sensitivity and high energy-efficiency photo-sensing. The proposed CMOS biosensor is implemented in $\mathrm {a}0 .18- \mu m$ CMOS technology, consuming $41 \mu W$ from $\mathrm {a}1 .8- V$ supply voltage, while achieving a peak dynamic range of $86 dB$ over a $50- Hz$ input bandwidth at a 20-kS/s sampling rate. This new interface opens new avenues for conducting in-vivo experiments with live animals.

PMID:
30440700
DOI:
10.1109/EMBC.2018.8512653
[Indexed for MEDLINE]

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