Low-noise Transimpedance Amplifier Design using Chopper-stabilized Technique for Nanopore Applications

Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul:2018:1-4. doi: 10.1109/EMBC.2018.8513397.

Abstract

This paper presents a low-noise transimpedance amplifier (TIA) employing chopper-stabilized technique for nanopore applications. The TIA, which is used as a headstage for the monitoring system, must achieve low-noise performance to accurately measure a minute ionic current signal generated from the nanopore. In this work, we analyze detailed input- referred noise current of the capacitive-feedback TIA and propose a core amplifier adopting the chopper-stabilized technique to effectively reduce flicker noise in a bandwidth of interest for nanopore applications. This proposed circuit schematic is designed by harnessing 0.35 $\mu \mathrm{m}$ CMOS process and is verified using elaborate simulation results.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amplifiers, Electronic*
  • Cardiography, Impedance
  • Electrocardiography / methods
  • Nanopores*
  • Noise