Send to

Choose Destination
J Clin Epidemiol. 2018 Nov 12. pii: S0895-4356(18)30566-3. doi: 10.1016/j.jclinepi.2018.11.002. [Epub ahead of print]

The TRIP database showed most Acute Respiratory Infections questions were already addressed by Cochrane reviews.

Author information

Centre for Research in Evidence-Based Practice, Bond University, Robina, 4226, Australia. Electronic address:
Centre for Research in Evidence-Based Practice, Bond University, Robina, 4226, Australia.
Trip Database Ltd., Newport, NP20 3PS, UK.



Cochrane systematic reviews require more methodological support from Cochrane Review Groups (CRGs) than is customary in journals, CRGs must prioritise reviews to conserve resources. The TRIP database provided a dataset of questions to guide prioritization for the Acute Respiratory Infections (ARI) CRG.


We extracted the ARI searches from the TRIP database (2010 to 2017) that contained at least one disease and one clinical management term, (defined as a 'search'), and tabulated these by frequency.


There were 314,346 ARI searches from which we inferred 45,497 clinical questions, covering 365 topics. In two thirds (30,541) these addressed only 20 clinical questions, of which treatment were the most frequent; followed by diagnosis, mortality and prognosis. The 5 most frequent clinical questions were "Influenza + Vaccination" 4,989 (12.1%), "acute otitis media + antibiotics" 3578 (8.7%), "common cold + vitamin C" 3528 (8.6%), "meningitis + corticosteroids" 1,910 (4.6%), "pneumonia + general treatment" 1765 (4.3%). The 20 most frequent clinical questions were addressed by Cochrane reviews or protocols.


ARI questions are common and repeated often. Most may have been addressed by Cochrane reviews. The remainder form the basis of a priority list to assign resources for future Cochrane topics.


Acute respiratory infections; Clinical questions; Cochrane; Database analysis; Health priorities; Research prioritization

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center