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Int J Biol Macromol. 2019 Feb 15;123:531-538. doi: 10.1016/j.ijbiomac.2018.11.087. Epub 2018 Nov 13.

Extraction and antioxidant activities of polysaccharides from roots of Arctium lappa L.

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College of Science, Sichuan Agriculture University, Ya'an 625014, China.
Guizhou Business and Economics Vocational College of Technology, Duyun 558022, China.
Qiannan Normal University for Nationalities, Duyun 558000, China.
Triticeae Research Institute, Sichuan Agricultural University, Wenjiang, Sichuan 611130, China.
Agricultural Information and Rural Economy Institute of Sichuan Academy of Agricultural Science, Chengdu 610066, China.
College of Science, Sichuan Agriculture University, Ya'an 625014, China. Electronic address:


Polysaccharides were extracted from the roots of Arctium lappa L. (ALPs) using response surface methodology with ultrasonication. A central composition design was used to optimize extraction parameters by maximizing the polysaccharide extraction yield. The modified optimal conditions were as follows: water to raw material ratio of 31 mL/g, ultrasonic power of 158 W, extraction time of 83 min, and extraction temperature of 50 °C. Furthermore, fractions of ALP40-1, ALP60-1, and ALP80-1 were obtained for chemical and antioxidant activity analyses after purification. Results indicated that the three fractions had a molecular weight of 218, 178, and 60 kDa, respectively, and were composed of mannose, glucose, fructose, and galactose. ALP60-1 exhibited strong scavenging activities on 1,1‑diphenyl‑2‑picryhydrazyl, hydroxyl, and superoxide radicals. These results demonstrate that ultrasonic-assisted extraction is a very effective method for extracting ALPs, and ALP60-1 is a potential novel natural antioxidant. However, further structure elucidation and in vivo experiments are required.


Antioxidant activities; Arctium lappa L.; Polysaccharides; Ultrasonic-assisted extraction

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