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Clin Transplant. 2019 Jan;33(1):e13449. doi: 10.1111/ctr.13449. Epub 2018 Dec 12.

Implementation of a transition model to adult care may not be enough to improve results: National study of kidney transplant recipients.

Author information

1
Pediatric Research Center, Children's Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
2
Department of Pediatric Nephrology and Transplantation, Children's Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
3
Abdominal Center/Nephrology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

Abstract

Adolescents with a kidney transplant (KT) require special attention during the transition of care. Few longitudinal studies have assessed the effect of transition models (TM) on patient outcomes. Between 1986 and 2013, 239 pediatric patients underwent KT in Finland, of whom 132 have been transferred to adult care. In 2005, a TM was developed following international recommendations. We compared patient (PS) and graft survival (GS) rates before and after the introduction of the TM. PS and GS at 10 years were similar before and after the implementation of the TM (PS 85% and 90% respectively, P = 0.626; GS 60% and 58%, respectively, P = 0.656). GS was lower in patients transplanted at age 10-18 than in patients transplanted at a younger age in the TM cohort (79% vs 95%, P < 0.001). During the first five years after transfer, 63% of patients had stable KT function, 13% had deteriorating function and 24% lost their KT. Altogether 32 out of 132 patients lost their kidney allograft within five years after transfer to adult care (13 before and 19 after TM implementation, P = 0.566). The implementation of this TM had no effect on PS or GS. Further measures to improve our TM are in progress.

KEYWORDS:

adolescents; kidney transplantation; survival; transition; young adults

PMID:
30431669
DOI:
10.1111/ctr.13449

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