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Arch Environ Occup Health. 2018 Nov 15:1-12. doi: 10.1080/19338244.2018.1535480. [Epub ahead of print]

POPs' effect on cardiometabolic and inflammatory profile in a sample of women with obesity and hypertension.

Author information

1
a CINTESIS - Center for Research in Health Technologies and Information Systems , Porto , Portugal.
2
b Interno de Formação Específica - Medicina Interna, Pedro Hispano General Hospital Matosinhos , Matosinhos , Portugal.
3
c Nutrition & Metabolism , NOVA Medical School|Faculdade de Ciências Médicas, Universidade Nova de Lisboa , Lisboa , Portugal.
4
d Comprehensive Health Research Centre, NOVA Medical School|Faculdade de Ciências , Médicas , Universidade Nova de Lisboa , Lisboa , Portugal.
5
e Department of Biochemistry, Faculty of Medicine , University of Porto, Centro de Investigação Médica , Porto , Portugal.
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f Instituto de Investigação e Inovação em Saúde, University of Porto , Porto , Portugal.
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g Faculty of Medicine , University of Porto , Porto , Portugal.
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h REQUIMTE/LAQV-GRAQ - Instituto Superior de Engenharia, Instituto Politécnico do Porto , Porto , Portugal.
9
i Unit of Hypertension, Pedro Hispano General Hospital Matosinhos , Matosinhos , Portugal.

Abstract

Persistent organic pollutants (POPs) are man-made compounds with metabolic disruption impact. We investigated the effect of POP exposure in the cardiometabolic and inflammatory profile in a population of women with obesity and hypertension. In 43 premenopausal women (22 treated vs. 21 nontreated) undergoing bariatric surgery, blood and adipose tissue samples (visceral (vAT) and abdominal subcutaneous (scAT)) were collected. Median concentrations of ∑HCH and ∑POPs in vAT were significantly higher in treated women. VAT ∑HCH and scAT ∑HCH and ∑POPs concentrations were positively correlated with systolic blood pressure in the non-treated group. Our findings suggest that exposure to POPs and its accumulation in vAT and circulating in plasma may be associated to a higher cardiovascular risk in women with obesity and hypertension, with or without antihypertensive treatment.

KEYWORDS:

Cardiometabolic risk; hypertension; inflammation; obesity; persistent organic pollutants

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