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Exp Neurobiol. 2018 Oct;27(5):377-386. doi: 10.5607/en.2018.27.5.377. Epub 2018 Oct 31.

Ubiquitin C-terminal Hydrolase L1 Regulates Lipid Raft-dependent Endocytosis.

Kang SJ1,2,3, Kim JS1,2, Park SM1,2,3.

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Department of Pharmacology, Ajou University School of Medicine, Suwon 16499, Korea.
Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon 16499, Korea.
BK21 plus program, Department of Biological Sciences, Ajou University School of Medicine, Suwon 16499, Korea.


Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a deubiquitinating enzyme that is highly expressed in neurons, and gathering evidence indicates that UCH-L1 may play pathogenic roles in many neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease (PD). Additionally, lipid rafts have attracted interest in neurodegeneration as playing a common role in many neurodegenerative diseases. In the present study, we demonstrated that UCH-L1 associates with lipid rafts as with other PD-associated gene products. In addition, UCH-L1 regulates lipid raft-dependent endocytosis and it is not dependent on the expression and degradation of caveolin-1 or flotillin-1. Finally, UCH-L1 regulates cell-to-cell transmission of α-synuclein. This study provides evidence that many PD-associated gene products share common signaling pathways to explain the pathogenesis of PD.


Parkinson's disease; UCH-L1; alpha-synuclein; prion disease

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