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Exp Neurobiol. 2018 Oct;27(5):377-386. doi: 10.5607/en.2018.27.5.377. Epub 2018 Oct 31.

Ubiquitin C-terminal Hydrolase L1 Regulates Lipid Raft-dependent Endocytosis.

Kang SJ1,2,3, Kim JS1,2, Park SM1,2,3.

Author information

1
Department of Pharmacology, Ajou University School of Medicine, Suwon 16499, Korea.
2
Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon 16499, Korea.
3
BK21 plus program, Department of Biological Sciences, Ajou University School of Medicine, Suwon 16499, Korea.

Abstract

Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a deubiquitinating enzyme that is highly expressed in neurons, and gathering evidence indicates that UCH-L1 may play pathogenic roles in many neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease (PD). Additionally, lipid rafts have attracted interest in neurodegeneration as playing a common role in many neurodegenerative diseases. In the present study, we demonstrated that UCH-L1 associates with lipid rafts as with other PD-associated gene products. In addition, UCH-L1 regulates lipid raft-dependent endocytosis and it is not dependent on the expression and degradation of caveolin-1 or flotillin-1. Finally, UCH-L1 regulates cell-to-cell transmission of α-synuclein. This study provides evidence that many PD-associated gene products share common signaling pathways to explain the pathogenesis of PD.

KEYWORDS:

Parkinson's disease; UCH-L1; alpha-synuclein; prion disease

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