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Exp Neurobiol. 2018 Oct;27(5):344-349. doi: 10.5607/en.2018.27.5.344. Epub 2018 Oct 31.

Circadian Regulation by REV-ERBα Mediates Hippocampal E-LTP in a Time-dependent Manner.

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School of Biological Sciences, Seoul National University, Seoul 08826, Korea.
Department of Brain and Cognitive Sciences, DGIST, Daegu 42988, Korea.


Circadian rhythms are driven by circadian oscillators, and these rhythms result in the biological phenomenon of 24-h oscillations. Previous studies suggest that learning and memory are affected by circadian rhythms. One of the genes responsible for generating the circadian rhythm is Rev-erbα. The REV-ERBα protein is a nuclear receptor that acts as a transcriptional repressor, and is a core component of the circadian clock. However, the role of REV-ERBα in neurophysiological processes in the hippocampus has not been characterized yet. In this study, we examined the time-dependent role of REV-ERBα in hippocampal synaptic plasticity using Rev-erbα KO mice. The KO mice lacking REV-ERBα displayed abnormal NMDAR-dependent synaptic potentiation (E-LTP) at CT12~CT14 (subjective night) when compared to their wild-type littermates. However, Rev-erbα KO mice exhibited normal E-LTP at CT0~CT2 (subjective day). We also found that the Rev-erbα KO mice had intact late LTP (L-LTP) at both subjective day and night. Taken together, these results provide evidence that REV-ERBα is critical for hippocampal E-LTP during the dark period.


Circadian clock system; Circadian rhythm; Long-term potentiation; Neuronal plasticity

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