Format

Send to

Choose Destination
Mol Nutr Food Res. 2018 Nov 14:e1800512. doi: 10.1002/mnfr.201800512. [Epub ahead of print]

Body Mass Index as a Determinant of Systemic Exposure to Gallotannin Metabolites during 6-Week Consumption of Mango (Mangifera indica L.) and Modulation of Intestinal Microbiota in Lean and Obese Individuals.

Author information

1
Department of Nutrition and Food Science, Texas A&M University, College Station, 77843, TX, USA.
2
Gastrointestinal Laboratory, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, 77843, TX, USA.
3
Center for Translational Research in Aging and Longevity, Department of Health and Kinesiology, Texas A&M University, College Station, 77843, TX, USA.
4
Therapeutic Microbiology Laboratory, Department of Molecular Virology and Microbiology, Alkek Center for Metagenomics and Microbiome Research, Baylor College of Medicine, Houston, 77030, TX, USA.

Abstract

SCOPE:

This human clinical pilot trial investigated pharmacokinetics of gallotannin-metabolites and modulation of intestinal microbiota in healthy lean and obese individuals after 6 weeks of daily mango consumption.

METHODS AND RESULTS:

Participants are divided into three groups: Lean Mango (LM: n = 12; BMI = 22.9 kg m-2 ), Obese Mango (OM: n = 9; BMI = 34.6 kg m-2 ), and Lean Control (LC: n = 11; BMI = 22.1 kg m-2 ). LM and OM consumed 400 g of mango per day for 6 weeks. LC consumed mango only on Days 0 and 42. After 6 weeks, LM experienced increased systemic exposure (AUC0-8h ) to gallotannin-metabolites, 1.4-fold (p = 0.043). The greatest increase is 4-O-methyl-gallic acid, 3.3-fold (p = 0.0026). Cumulative urinary excretion of gallotannin-metabolites significantly increased in LM and OM, but not LC. For OM, qPCR data show increased levels of tannase-producing Lactococcus lactis and decreased levels of Clostridium leptum and Bacteroides thetaiotaomicron, bacteria associated with obesity. LM experienced an increased trend of fecal levels of butyric (1.3-fold; p = 0.09) and valeric acids (1.5-fold; p = 0.056). Plasma endotoxins showed a decreased trend in LM and OM.

CONCLUSION:

Continuous mango intake significantly increased systemic exposure to gallotannin- metabolites and induced an increased trend for fecal short-chain fatty acids in lean but not obese individuals. This pharmacokinetic discrepancy may result in BMI-associated reduced gallotannin-derived health benefits.

KEYWORDS:

bioavailability; gallotannins; human clinical intervention; intestinal microbiota; mango

PMID:
30427574
DOI:
10.1002/mnfr.201800512

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center