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J Dermatolog Treat. 2018 Nov 14:1-18. doi: 10.1080/09546634.2018.1544406. [Epub ahead of print]

5-aminolevulinic acid photodynamic therapy for condyloma acuminatum of urethral meatus.

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a Department of Dermatology and Venereology , Nanfang hospital, Southern Medical University , Guangzhou , 510515 , China.


Condyloma acuminatum are the most common sexually transmitted diseases worldwide, and they are closely associated with human papillomavirus (HPV) infections. Urethral meatus warts are uncommon. And many treatments are limited by a difficult approach, recurrences, and potential complications. In our study, 21 patients diagnosed with urethral condyloma acuminatum were included. After 4h treatment of 5-aminolevulinic acid (ALA), patients received photodynamic therapy (PDT). Each patient received HPV test before every PDT cycle. The frequency of PDT was dependent on viral load changes. As a result, all patients achieved complete clinical remission after the last session of ALA-PDT. There were significant differences in HPV viral loads between pretherapy and after one or three rounds of PDT treatment. So we concluded that ALA-PDT is a safe and effective method for treatment of condyloma acuminatum in urethra meatus. Dynamic monitoring of HPV viral loads can more objectively demonstrate the effectiveness and guide the treatment of PDT.


ALA-PDT; HPV; condyloma acuminatum; urethral meatus

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