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Alzheimers Dement (Amst). 2018 Sep 27;10:688-697. doi: 10.1016/j.dadm.2018.08.011. eCollection 2018.

Altered functional connectivity strength in informant-reported subjective cognitive decline: A resting-state functional magnetic resonance imaging study.

Dong C1, Liu T1,2,3, Wen W4,5, Kochan NA4,5, Jiang J4,5, Li Q1, Liu H1, Niu H1,3, Zhang W6, Wang Y6, Brodaty H2,7, Sachdev PS4,5,7.

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School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University, Beijing, China.
Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, China.
Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, NSW, Australia.
Beijing TianTan Hospital, Capital Medical University, Beijing, China.
Dementia Collaborative Research Centre, University of New South Wales, Sydney, NSW, Australia.



Informant-reported subjective cognitive decline (iSCD) has been associated with a higher risk of conversion to dementia, but the findings of whole brain functional connectivity strength (FCS) changes in iSCD are limited.


The sample comprised 39 participants with iSCD and 39 age- and sex- matched healthy controls. The global absolute (aFCS) and relative functional connectivity strengths were estimated using weighted degree centrality and the z-scores of the weighted degree centrality respectively. FreeSurfer was used for measuring cortical thickness.


The aFCS was lower in iSCD primarily in left medial superior frontal, left precuneus, left parietal, right cuneus, and bilateral calcarine; while relative functional connectivity strength was higher in posterior cingulate cortex/precuneus compared with healthy controls. No significant differences in cortical thickness were observed.


There are detectable changes of FCS in iSCD, with the precuneus possibly playing a compensatory role. FCS could therefore have a potential role to serve as one of the earliest neuroimaging markers of neurodegenerative disease.


Aging; Functional connectivity strength; Preclinical Alzheimer's disease; Precuneus; Subjective cognitive decline

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