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Nutrients. 2018 Nov 12;10(11). pii: E1734. doi: 10.3390/nu10111734.

Chokeberry Extract and Its Active Polyphenols Suppress Adipogenesis in 3T3-L1 Adipocytes and Modulates Fat Accumulation and Insulin Resistance in Diet-Induced Obese Mice.

Author information

1
Gyeongnam Department of Environment & Toxicology, Korea Institute of Toxicology, 17 Jegok-gil, Munsan-eup 52834, Korea. nhkim@kitox.re.kr.
2
College of Pharmacy, Pusan National University, Busan 46241, Korea. jhjegal@pusan.ac.kr.
3
Department of Agronomy and Medicinal Plant Resources, Gyeongnam National University of Science and Technology, Jinju 52725, Korea. skdbssk@hanmail.net.
4
Gyeongnam Department of Environment & Toxicology, Korea Institute of Toxicology, 17 Jegok-gil, Munsan-eup 52834, Korea. jdheo@kitox.re.kr.
5
Department of Oceanography, Kunsan National University, Kunsan 54150, Korea. jrrho@kunsan.ac.kr.
6
College of Pharmacy, Pusan National University, Busan 46241, Korea. mhyang@pusan.ac.kr.
7
Department of Agronomy and Medicinal Plant Resources, Gyeongnam National University of Science and Technology, Jinju 52725, Korea. ejjeong@gntech.ac.kr.

Abstract

Berries of Aronia melanocarpa (chokeberry) are known to be a rich source of biologically active polyphenols. In the present study, the effects of seven anti-adipogenic polyphenolic phytochemicals isolated from A. melanocarpa methanol extract on adipogenic transcription factors were investigated. Amygdalin and prunasin were found to inhibit 3T3-L1 adipocyte differentiation by suppressing the expressions of PPARγ (peroxisome proliferator-activated receptor γ), C/EBPα (CCAAT/enhancer binding protein α), SREBP1c (sterol regulatory element binding protein 1c), FAS (fatty acid synthase), and aP2 (adipocyte fatty-acid⁻binding protein). A. melanocarpa extract-treated (100 or 200 mg/kg/day on body weight) high fat diet (HFD)-induced obese mice showed significant decreases in body weight, serum triglyceride (TG), and low-density lipoprotein cholesterol (LDLC) levels and improved insulin sensitivity as compared with HFD controls. This research shows A. melanocarpa extract is potentially beneficial for the suppression of HFD-induced obesity.

KEYWORDS:

Aronia melanocarpa; adipogenic transcription factor; anti-adipogenesis; diet-induced obesity; insulin resistance; polyphenols

PMID:
30424495
PMCID:
PMC6266992
DOI:
10.3390/nu10111734
[Indexed for MEDLINE]
Free PMC Article

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