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Mov Disord. 2018 Nov;33(11):1809-1813. doi: 10.1002/mds.27518. Epub 2018 Nov 13.

Ratios of proteins in cerebrospinal fluid in Parkinson's disease cognitive decline: prospective study.

Author information

1
Neurodegenerative Disorders Area, Biodonostia Health Research Institute, San Sebastián, Spain.
2
Biomedical Research Networking Centre Consortium for the area of Neurodegenerative Diseases (CIBERNED), Madrid, Spain.
3
Genomics Platform, Biodonostia Research Institute, San Sebastián, Spain.
4
Clinica Universidad de Navarra, Center for Applied Medical Research (CIMA)-Universidad de Navarra, Pamplona, Spain.
5
Movement Disorders Unit, Department of Neurology, University Hospital Donostia, San Sebastián, Spain.
6
Ikerbasque (Basque Foundation for Science), Bilbao, Spain.
7
Basque Center on Cognition Brain and Language (BCBL), San Sebastián, Spain.

Abstract

BACKGROUND:

There is a need for biomarkers of dementia in PD.

OBJECTIVES:

To determine if the levels of the main CSF proteins and their ratios are associated with deterioration in cognition and progression to dementia in the short to mid term.

METHODS:

The Parkinson's Progression Markers Initiative database was used as an exploratory cohort, and a center-based cohort was used as a replication cohort. Amyloid ß1-42, total tau, threonine-181 phosphorylated tau, and α-synuclein in the CSF and the ratios of these proteins were assessed.

RESULTS:

In the Parkinson's Progression Markers Initiative cohort (n = 281), the total tau/amyloid ß1-42, total tau/α-synuclein, total tau/amyloid ß1-42+α-synuclein, and amyloid ß1-42/total tau ratios were associated with a risk of progression to dementia over a 3-year follow-up. In the replication cohort (n = 40), the total tau/α-synuclein and total tau/amyloid ß1-42+α-synuclein ratios were associated with progression to dementia over a 41-month follow-up.

CONCLUSION:

Ratios of the main proteins found in PD patient brain inclusions that can be measured in the CSF appear to have value as short- to mid-term predictors of dementia. © 2018 International Parkinson and Movement Disorder Society.

KEYWORDS:

Parkinson's disease; biomarkers; cerebrospinal fluid; dementia; protein ratios

PMID:
30423201
DOI:
10.1002/mds.27518

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