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Menopause. 2019 Apr;26(4):409-416. doi: 10.1097/GME.0000000000001258.

The association of miR-25T>C, miR-32C>A, miR-125C>T, and miR-222G>T polymorphisms with a risk of primary ovarian insufficiency in Korean women.

Author information

1
Department of Biomedical Science, College of Life Science, CHA University, Seongnam, Korea.
2
Department of Obstetrics and Gynecology, School of Medicine, CHA University, Seongnam, Korea.
3
Fertility Center of CHA Gangnam Medical Center, CHA University, Seoul, Korea.

Abstract

OBJECTIVE:

The purpose of this study was to investigate the association of microRNA polymorphisms (miR-25T>C, miR-32C>A, miR-125C>T, and miR-222G>T) with primary ovarian insufficiency (POI) in Korean women.

METHODS:

We conducted a case-control study of Korean women: 142 participants with POI and 266 controls with at least 1 live birth and no history of pregnancy loss.

RESULTS:

The haplotype-based multifactor dimensionality reduction analysis revealed that the T-C-T-G (miR-25/-32/-125/-222), T-A-C-G (miR-25/-32/-125/-222), C-T-G (miR-32/-125/-222), A-C-G (miR-32/-125/-222), T-G (miR-122/-222), C-T (miR-32/-125), and C-C (miR-25/-32) inferred haplotypes were significantly less frequent in POI (Pā€Š<ā€Š0.05), which suggested potential protective effects. Participants with POI had significantly increased luteinizing hormone levels (Pā€Š<ā€Š0.05), but hormonal levels, including luteinizing hormone, were not significantly different between POI women and control women with miR-32/-125/-222.

CONCLUSIONS:

After considering multiple comparisons, we concluded that miR-25T>C, miR-32C>A, miR-125C>T, and miR-222G>T had no relation with POI.

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