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Menopause. 2019 Apr;26(4):409-416. doi: 10.1097/GME.0000000000001258.

The association of miR-25T>C, miR-32C>A, miR-125C>T, and miR-222G>T polymorphisms with a risk of primary ovarian insufficiency in Korean women.

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Department of Biomedical Science, College of Life Science, CHA University, Seongnam, Korea.
Department of Obstetrics and Gynecology, School of Medicine, CHA University, Seongnam, Korea.
Fertility Center of CHA Gangnam Medical Center, CHA University, Seoul, Korea.



The purpose of this study was to investigate the association of microRNA polymorphisms (miR-25T>C, miR-32C>A, miR-125C>T, and miR-222G>T) with primary ovarian insufficiency (POI) in Korean women.


We conducted a case-control study of Korean women: 142 participants with POI and 266 controls with at least 1 live birth and no history of pregnancy loss.


The haplotype-based multifactor dimensionality reduction analysis revealed that the T-C-T-G (miR-25/-32/-125/-222), T-A-C-G (miR-25/-32/-125/-222), C-T-G (miR-32/-125/-222), A-C-G (miR-32/-125/-222), T-G (miR-122/-222), C-T (miR-32/-125), and C-C (miR-25/-32) inferred haplotypes were significantly less frequent in POI (Pā€Š<ā€Š0.05), which suggested potential protective effects. Participants with POI had significantly increased luteinizing hormone levels (Pā€Š<ā€Š0.05), but hormonal levels, including luteinizing hormone, were not significantly different between POI women and control women with miR-32/-125/-222.


After considering multiple comparisons, we concluded that miR-25T>C, miR-32C>A, miR-125C>T, and miR-222G>T had no relation with POI.

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