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Obesity (Silver Spring). 2019 Jan;27(1):22-29. doi: 10.1002/oby.22303. Epub 2018 Nov 13.

Effectiveness of a Total Meal Replacement Program (OPTIFAST Program) on Weight Loss: Results from the OPTIWIN Study.

Author information

1
Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.
2
Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA.
3
AMITA Health, Alexian Brothers Weight Loss Solutions, Elk Grove Village, Illinois, USA.
4
Alaska Premier Health, Anchorage, Alaska, USA.
5
EpidStat Institute, Ann Arbor, Michigan, USA.
6
The Central Ohio Nutrition Center, Inc., Gahanna, Ohio, USA.
7
Department of Surgery, East Carolina University Brody School of Medicine, Greenville, North Carolina, USA.
8
Nestlé Health Science, U.S. Clinical Operations, Bridgewater, New Jersey, USA.

Abstract

OBJECTIVE:

The aim of this study was to test the effectiveness of the OPTIFAST program (OP), a total meal replacement dietary intervention, compared with a food-based (FB) dietary plan for weight loss.

METHODS:

Participants with BMI 30 to 55 kg/m2 , age 18 to 70 years old, were randomized to OP or FB dietary and lifestyle interventions for 26 weeks, followed by a weight-maintenance phase. Outcomes were percent change in body weight (%WL) from baseline to weeks 26 and 52, associated changes in body composition (using dual energy x-ray absorptiometry), and adverse events. Primary analysis used repeated-measures multivariable linear mixed models to compare outcomes between groups in a modified intention-to-treat fashion (mITT).

RESULTS:

A total of 273 participants (83% of randomized; 135 OP, 138 FB) made up the mITT population. Mean age was 47.1 ± 11.2 years; 82% were female and 71% non-Hispanic white. Baseline BMI was 38.8 ± 5.9 kg/m2 . At 26 weeks, OP %WL was 12.4% ± 0.6% versus 6.0% ± 0.6% in FB (P < 0.001). At 52 weeks, OP %WL was 10.5% ± 0.6% versus 5.5% ± 0.6% in FB (P < 0.001). Fat mass loss was greater for OP; lean mass loss was proportional to total weight loss. There was no difference in serious adverse event rates between groups.

CONCLUSIONS:

Compared with an FB approach, OP was more effective with greater sustained weight loss.

PMID:
30421863
DOI:
10.1002/oby.22303

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