Send to

Choose Destination
BMC Gastroenterol. 2018 Nov 12;18(1):174. doi: 10.1186/s12876-018-0899-3.

Clinical characteristics of hepatic Arterioportal shunts associated with hepatocellular carcinoma.

Author information

Department of Intervention, Shandong Tumor Hospital Affiliated to Shandong University, Jinan, 250117, China.
Department of Radiotherapy, Shandong Tumor Hospital Affiliated to Shandong University, Jinan, 250117, China.
Department of pathology, Shandong Tumor Hospital Affiliated to Shandong University, Jinan, 250117, China.
Department of Thoracic Oncology Surgery, Shandong Tumor Hospital Affiliated to Shandong University, No. 440, Jiyan Road, Jinan, 250117, China.



Hepatic arterioportal shunt (A-P shunt) is defined as the direct blood flow established between hepatic artery and portal venous system; it is frequently observed in patients with hepatocellular carcinoma (HCC). Clinically, it is important to diagnose HCC associated A-P shunts, as it may impact the treatment strategy of the patients. In the present study, we described the imaging findings of the HCC associated A-P shunts and discussed the treatments strategy of such patients. From the findings, we also discussed the potential cause of A-P shunts.


Clinical data of HCC patients (n = 560), admitted to the hospital between April 2012 to April 2014, were reviewed. Hepatic angiography was used to examine the presence of A-P shunts. Of the 137 patients with A-P shunts, grading of the A-P shunts was performed, and statistical analysis of the different grades of A-P shunts and clinical characteristics was performed.


The hepatic angiography confirmed that 99 patients had typical A-P shunts (Grade 1-3), and 38 patients had atypical A-P shunts. Embolization was the main strategy used to treat A-P shunts, in which liquid embolic agents appeared to provide a better treatment outcome. The correlation analysis showed that the grading of portal vein tumor thrombus was significantly associated with the grading of A-P shunt (p = < 0.001, Spearman correlation coefficient was 0.816 ± 0.043).


We characterized A-P shunts and proposed treatment strategy for treating HCC patients with various levels of A-P shunts. The findings supported the hypothesis that the formation of HCC associated A-P shunts was caused by tumor thrombus.


Hepatic arterioportal shunts; Hepatocellular carcinoma; Portal vein tumor embolus; Transarterial chemoembolization

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center