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Drug Alcohol Depend. 2019 Jan 1;194:107-111. doi: 10.1016/j.drugalcdep.2018.09.024. Epub 2018 Nov 3.

Alcohol consumption and S-Klotho plasma levels in sedentary healthy middle-aged adults: A cross sectional study.

Author information

1
Department of Medical Physiology, School of Medicine, University of Granada, Spain. Electronic address: juradofasoli@ugr.es.
2
Department of Medical Physiology, School of Medicine, University of Granada, Spain; PROmoting FITness and Health through Physical Activity Research Group (PROFITH), Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Spain.
3
Department of Medical Physiology, School of Medicine, University of Granada, Spain.
4
Department of Medical Physiology, School of Medicine, University of Granada, Spain. Electronic address: mcgarzon@ugr.es.

Abstract

INTRODUCTION:

Alcohol consumption is related to several diseases and injuries that accelerate the ageing process and increase the mortality and morbidity risk. The soluble form of the α-Klotho gene (called S-Klotho) is widely considered as a powerful anti-ageing biomarker.

AIM:

The aim of the present study was to analyze the association between alcohol consumption and S-Klotho plasma levels in sedentary middle-aged adults.

METHODS:

74 (39 women) middle-aged sedentary adults (40-65 years old) participated in the present study. Alcohol consumption was assessed with a food frequency questionnaire previously validated and with three non-consecutive 24-hours recall. The S-Klotho plasma levels were measured by ELISA using a soluble α-Klotho ELISA assay kit.

RESULTS:

Total alcoholic drinks consumption was negatively associated with S-Klotho plasma levels (β=-17.031; R2 = 0.096, P = 0.013). Furthermore, we observed that higher consumption of total alcoholic drinks is associated with lower S-Klotho plasma levels in middle-aged sedentary adults controlling for BMI (β=-16.372; R2 = 0.201, P = 0.011), LMI (β=-31.854; R2 = 0.305, P = 0.010) and for FMI β=-13.337; R2 = 0.075, P = 0.049).

CONCLUSION:

In conclusion, our study shows that total alcoholic drinks consumption is negatively associated with the S-Klotho plasma levels in middle-aged sedentary adults.

KEYWORDS:

Ageing; Alcohol; Alcohol drinking; Klotho

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