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Brain Behav. 2018 Nov 12:e01155. doi: 10.1002/brb3.1155. [Epub ahead of print]

Methylphenidate promotes the interaction between motor cortex facilitation and attention in healthy adults: A combined study using event-related potentials and transcranial magnetic stimulation.

Author information

1
Department of Psychiatry, Neurology, Psychosomatics, Psychotherapy in Childhood and Adolescence, University Medical Center of Rostock, Rostock, Germany.

Abstract

OBJECTIVE:

This study investigated simultaneously the impact of methylphenidate (MPH) on the interaction of inhibitory and facilitative pathways in regions processing motor and cognitive functions.

METHOD:

Neural markers of attention and response control (event-related potentials) and motor cortical excitability (transcranial magnetic stimulation) and their pharmacological modulation by MPH were measured simultaneously in a sample of healthy adults (n = 31) performing a cued choice reaction test.

RESULTS:

Methylphenidate modulated attentional gating and response preparation processes (increased contingent negative variation) and response inhibition (increased nogo P3). N1, cue- and go-P3 were not affected by MPH. Motor cortex facilitation, measured with long-interval cortical facilitation, was increased under MPH in the nogo condition and was positively correlated with the P3 amplitude.

CONCLUSION:

Methylphenidate seems particularly to enhance response preparation processes. The MPH-induced increased motor cortex facilitation during inhibitory task demands was accompanied by increased terminal response inhibition control, probably as a compensatory process.

KEYWORDS:

CNV; ICF; P3; SICF; attention; event-related potentials; methylphenidate; motor control; transcranial magnetic stimulation

PMID:
30417982
DOI:
10.1002/brb3.1155
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