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Clin Pharmacol Ther. 2019 Jan;105(1):39-41. doi: 10.1002/cpt.1262. Epub 2018 Nov 11.

Regenerative Prophylaxis In Utero.

Author information

1
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota, USA.
2
Division of Neonatal Medicine, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, USA.
3
Center for Regenerative Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Abstract

Technology advances have raised the outlook for regenerative solutions aimed at restoring organ health. Fetal surgery, implemented to reinstate early organ growth and restitute function in select congenital conditions, is increasingly considered with the prospect of improved postnatal outcomes. Herein, we highlight clinical prenatal interventions for rescue of fetal lung development in congenital diaphragmatic hernia and fetal neurological regeneration for spina bifida. Regenerative therapeutic care in utero is poised to transform management algorithms.

PMID:
30417507
PMCID:
PMC6312471
[Available on 2020-01-01]
DOI:
10.1002/cpt.1262

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