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Alzheimers Dement. 2018 Dec;14(12):1651-1662. doi: 10.1016/j.jalz.2018.08.011. Epub 2018 Nov 8.

Military-related risk factors for dementia.

Author information

1
Medical & Scientific Relations, Alzheimer's Association, Chicago, IL, USA. Electronic address: hsnyder@alz.org.
2
Clinical Neuroanatomy, Equality and Diversity Lead, University of Southampton, Southampton, United Kingdom.
3
Department of Neurology and Neuroscience, University of Florida, Gainesville, FL, USA.
4
Department of Psychiatry, New York University Medical Center, New York City, NY, USA.
5
Department of Microbiology and Immunology, Miami University, Miami, FL, USA.
6
Gladstone Institute, University of California, San Francisco, San Francisco, CA, USA.
7
Department of Psychiatry, Neurology & Epidemiology, University of California, San Francisco, San Francisco, CA, USA.
8
Blast Injury Research Program Coordinating Office, United States Army Medical Research and Material Command, Frederick, MD, USA.
9
Stark Neurosciences Research Institute, Indiana University, Indianapolis, IN, USA.
10
Helen Willis Neuroscience Institute, University of California, Berkley, Berkley, CA, USA.
11
Department of Neurology and Pathology, Boston University, Boston, MA, USA.
12
Department of Pathology, Uniformed Services University, Bethesda, MD, USA.
13
Neurology Department, Rush University Medical Center, Chicago, IL, USA.
14
Department of Radiology, University of California San Francisco, San Francisco, CA, USA.
15
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
16
Independent Science Writer, Philadelphia, PA, USA.
17
Congressionally Directed Medical Research Programs, Frederick, MD, USA.
18
Medical & Scientific Relations, Alzheimer's Association, Chicago, IL, USA.

Abstract

INTRODUCTION:

In recent years, there has been growing discussion to better understand the pathophysiological mechanisms of traumatic brain injury and post-traumatic stress disorder and how they may be linked to an increased risk of neurodegenerative diseases including Alzheimer's disease in veterans.

METHODS:

Building on that discussion, and subsequent to a special issue of Alzheimer's & Dementia published in June 2014, which focused on military risk factors, the Alzheimer's Association convened a continued discussion of the scientific community on December 1, 2016.

RESULTS:

During this meeting, participants presented and evaluated progress made since 2012 and identified outstanding knowledge gaps regarding factors that may impact veterans' risk for later life dementia.

DISCUSSION:

The following is a summary of the invited presentations and moderated discussions of both the review of scientific understanding and identification of gaps to inform further investigations.

PMID:
30415806
PMCID:
PMC6281800
[Available on 2019-12-01]
DOI:
10.1016/j.jalz.2018.08.011
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