Format

Send to

Choose Destination
Cell Mol Life Sci. 2019 Mar;76(5):827-835. doi: 10.1007/s00018-018-2961-2. Epub 2018 Nov 10.

Mitochondrial dynamics and metastasis.

Author information

1
Prostate Cancer Discovery and Development Program and Immunology, Microenvironment and Metastasis Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA, 19104, USA. daltieri@wistar.org.

Abstract

Changes in cellular metabolism are now a recognized hallmark of cancer. Although this process is ripe with therapeutic potential in the clinic, its complexity and extraordinary plasticity have systematically defied dogmas and oversimplifications. Perhaps, best exemplifying this intricacy is the role of mitochondria in cancer, which in just a few years has gone from largely unnoticed to pivotal disease driver. The underlying mechanisms are only beginning to emerge. However, there is now clear evidence linking the dynamic nature of mitochondria to the machinery of tumor cell motility and metastatic spreading. These studies may open fresh therapeutic options for patients with disseminated cancer, currently an incurable and mostly lethal condition.

KEYWORDS:

Cancer; Dynamics; Metastasis; Mitochondria; Trafficking; Tumor cell invasion

PMID:
30415375
PMCID:
PMC6559795
[Available on 2020-03-01]
DOI:
10.1007/s00018-018-2961-2
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center