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J Allergy Clin Immunol Pract. 2018 Nov 8. pii: S2213-2198(18)30715-3. doi: 10.1016/j.jaip.2018.10.044. [Epub ahead of print]

Association between maternal pre-pregnancy body mass index, gestational weight gain, and offspring atopic dermatitis: a prospective cohort study.

Author information

1
Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Canada; Women's College Research Institute and Department of Medicine, Women's College Hospital, Toronto, Canada; Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, RI. Electronic address: aaron.drucker@wchospital.ca.
2
Faculty of Medicine, University of Toronto, Canada.
3
Department of Epidemiology, School of Public Health, Brown University, Providence, RI; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
4
Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, RI; Department of Epidemiology, School of Public Health, Brown University, Providence, RI; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
5
INSERM, U1168, VIMA: Aging and chronic diseases. Epidemiological and public health approaches, F-94807, Villejuif, France; Univ Versailles St-Quentin-en-Yvelines, UMR-S 1168, F-78180, Montigny le Bretonneux, France.
6
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Emergency Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.

Abstract

BACKGROUND:

Maternal weight status may contribute to the development of atopic disorders in children.

OBJECTIVE:

The objective of this study was to assess associations of maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) with risk of atopic dermatitis in children METHODS: Maternal pre-pregnancy BMI and GWG were assessed by questionnaire through the Growing Up Today Study (GUTS), a prospective cohort study of U.S. children. Mothers reported whether GUTS participants had ever been diagnosed with atopic dermatitis by a clinician in either 1997 or 1999, when GUTS participants were between 10-17 years old. We used multivariable logistic regression to estimate the association of BMI and GWG with atopic dermatitis in offspring (expressed as odds ratios (OR) with 95% confidence intervals).

RESULTS:

Among 13,269 GUTS participants, 2,058 (16%) had childhood atopic dermatitis. Higher maternal pre-pregnancy BMI was not associated with atopic dermatitis (p trend = 0.48). By contrast, GWG was associated with increased atopic dermatitis risk (p trend = 0.005). Compared to children of mothers who gained 25-34 lb, children of mothers who gained 35-44 lb (OR 1.11,0.98-1.26) and ≥45 lbs (OR 1.23,1.05-1.43) had an increased risk of atopic dermatitis. These associations appeared stronger with pre-pregnancy BMI >25 (GWG 35-44 lb: OR 1.20,0.84-1.69; GWG ≥45 lb: OR 1.57,1.07-2.31), but the statstical interaction between BMI and GWG was not significant.

CONCLUSION:

In this study, increased GWG was associated with increased risk of atopic dermatitis in offspring. This supports existing evidence that prenatal exposures contribute to the development of atopic disorders.

KEYWORDS:

atopic dermatitis; gestational weight gain; maternal BMI; perinatal; pregnancy; weight status

PMID:
30414948
DOI:
10.1016/j.jaip.2018.10.044

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