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World J Microbiol Biotechnol. 2018 Nov 9;34(11):172. doi: 10.1007/s11274-018-2551-3.

Exploring the rearrangement of sensory intelligence in proteobacteria: insight of Pho regulon.

Author information

1
Environmental Biotechnology and Genomics Division, National Environmental Engineering, Research Institute, CSIR-NEERI, Nagpur, 440020, India.
2
Environmental Biotechnology and Genomics Division, National Environmental Engineering, Research Institute, CSIR-NEERI, Nagpur, 440020, India. na_dafale@neeri.res.in.

Abstract

Pho regulon is a highly evolved and conserved mechanism across the microbes to fulfil their phosphate need. In this study, 52 proteobacteria genomes were analyzed for the presence of phosphorus acquisition genes, their pattern of arrangement and copy numbers. The diverse genetic architecture of the Pho regulon genes indicates the evolutionary challenge of nutrient limitation, particularly phosphorus, faced by bacteria in their environment. The incongruence between the Pho regulon proteins phylogeny and species phylogeny along with the presence of additional copies of pstS and pstB genes, having cross similarity with other genera, suggest the possibility of horizontal gene transfer event. The substitution rate analysis and multiple sequence alignment of the Pho regulon proteins were analyzed to gain additional insight into the evolution of the Pho regulon system. This comprehensive study confirms that genes perform the regulatory function (phoBR) were vertically inherited, whereas interestingly, genes whose product involved in direct interaction with the environment (pstS) acquired by horizontal gene transfer. The substantial amino acid substitutions in PstS most likely contribute to the successful adaptation of bacteria in different ecological condition dealing with different phosphorus availability. The findings decipher the intelligence of the bacteria which enable them to carry out the targeted alteration of genes to cope up with the environmental condition.

KEYWORDS:

Gene duplication; Horizontal gene transfer; Pho regulon; Phylogenetic tree incongruence; Rearrangement; Substitution rate

PMID:
30413888
DOI:
10.1007/s11274-018-2551-3
[Indexed for MEDLINE]

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