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Biochim Biophys Acta Gene Regul Mech. 2019 Mar;1862(3):394-402. doi: 10.1016/j.bbagrm.2018.10.013. Epub 2018 Nov 6.

Steering pluripotency and differentiation with N6-methyladenosine RNA modification.

Author information

1
Wallenberg Centre for Molecular Medicine (WCMM), Umeå University, SE-90185 Umeå, Sweden; Department of Medical Biosciences, Umeå University, SE-901 85 Umeå, Sweden.
2
Wallenberg Centre for Molecular Medicine (WCMM), Umeå University, SE-90185 Umeå, Sweden; Department of Medical Biosciences, Umeå University, SE-901 85 Umeå, Sweden. Electronic address: francesca.aguilo@umu.se.

Abstract

Chemical modifications of RNA provide a direct and rapid way to modulate the existing transcriptome, allowing the cells to adapt rapidly to the changing environment. Among these modifications, N6-methyladenosine (m6A) has recently emerged as a widely prevalent mark of messenger RNA in eukaryotes, linking external stimuli to an intricate network of transcriptional, post-transcriptional and translational processes. m6A modification modulates a broad spectrum of biochemical processes, including mRNA decay, translation and splicing. Both m6A modification and the enzymes that control m6A metabolism are essential for normal development. In this review, we summarized the most recent findings on the role of m6A modification in maintenance of the pluripotency of embryonic stem cells (ESCs), cell fate specification, the reprogramming of somatic cells into induced pluripotent stem cells (iPSCs), and differentiation of stem and progenitor cells. This article is part of a Special Issue entitled: mRNA modifications in gene expression control edited by Dr. Soller Matthias and Dr. Fray Rupert.

KEYWORDS:

Adipogenesis; Cellular differentiation; Embryonic stem cell; Epitranscriptomics; Hematopoietic stem cell; Induced pluripotent stem cell; METTL3; Myogenesis; N(6)-methyladenosine; Neurogenesis; RNA methylation; Spermatogenesis

PMID:
30412796
DOI:
10.1016/j.bbagrm.2018.10.013
[Indexed for MEDLINE]

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