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Tissue Eng Part A. 2019 Jul;25(13-14):1023-1036. doi: 10.1089/ten.TEA.2018.0202. Epub 2019 Jan 9.

Long-Term Cryopreservation and Revival of Tissue-Engineered Skeletal Muscle.

Author information

1
1Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois.
2
2Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, Urbana, Illinois.
3
3Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.
4
4Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia.
5
5Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois.

Abstract

The ability to freeze, revive, and prolong the lifetime of tissue-engineered skeletal muscle without incurring any loss of function represents a significant advancement in the field of tissue engineering. Cryopreservation enables the efficient fabrication, storage, and shipment of these tissues. This in turn facilitates multidisciplinary collaboration between research groups, enabling advances in skeletal muscle regenerative medicine, organ-on-a-chip models of disease, drug testing, and soft robotics. Furthermore, the observation that freezing undifferentiated skeletal muscle enhances functional performance may motivate future studies developing stronger and more clinically relevant engineered muscle.

KEYWORDS:

bioactuator; biobot; cryopreservation; cysteine cathepsins; skeletal muscle; tissue engineering

PMID:
30412045
DOI:
10.1089/ten.TEA.2018.0202

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