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Clin Cosmet Investig Dermatol. 2018 Oct 15;11:491-497. doi: 10.2147/CCID.S177697. eCollection 2018.

Skin hydration is significantly increased by a cream formulated to mimic the skin's own natural moisturizing systems.

Author information

Research and Development, Ego Pharmaceuticals Pty Ltd, Braeside, VIC, Australia,



Moisturizers are topical products designed to improve and maintain the skin barrier function and to help prevent dry skin.

Materials and methods:

A new moisturizer (Ceramide cream) was formulated containing ingredients which mimic the skin's own natural moisturizing systems. Corneometry was performed at baseline, 2, 4, 6 and 24 hours following a single application of Ceramide cream to healthy skin, and compared to three reference moisturizers available over-the-counter, and placebo. Transepidermal water loss (TEWL) was also measured following a single application of Ceramide cream compared to baseline, and its safety was assessed by repeat insult patch test, ophthalmologist and pediatric testing.


A single topical application of either the Ceramide cream or the three reference moisturizers resulted in a significant increase in skin hydration over time (P<0.001). The placebo cream did not significantly increase skin hydration at any time point. At 24 hours post-application, skin hydration measured for Ceramide cream was significantly greater (P<0.05) than that measured for all three of the reference moisturizers tested. Ceramide cream was also found to significantly decrease TEWL (P<0.001) over 24 hours, and was shown to be non-sensitizing to the skin of both adults and children and non-irritating to the skin, eyes and related eye area.


Ceramide cream increases skin hydration and improves barrier function which may make it suitable for use on dry skin.


ceramide; dry skin; emollient; humectant; moisturizer; natural moisturizing factor; occludent; stratum corneum; transepidermal water loss

Conflict of interest statement

Disclosure FS, TMB and KAG are employed by Ego Pharmaceuticals, Pty Ltd. The authors report no other conflicts of interest in this work.

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