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Drug Des Devel Ther. 2018 Oct 16;12:3485-3489. doi: 10.2147/DDDT.S169621. eCollection 2018.

The retinoprotective role of phenytoin.

Author information

1
Eye Clinic, Department of Medicine and Health Sciences "V. Tiberio," University of Molise, Campobasso, Italy, flaviachiosi@yahoo.it.
2
Department of Surgical Science, Ophthalmic Clinic, University of L'Aquila, L'Aquila, Italy.
3
Eye Clinic, University of Catania, Catania, Italy.
4
Department of Ophthalmology, University della Campania Luigi Vanvitelli, Naples, Italy.
5
Department of Health, University of Witten/Herdecke, Witten, Germany.

Abstract

Phenytoin is a non-sedative barbiturate derivate and has been recently rediscovered as a neuroprotective and retinoprotective compound in patients affected by optic neuritis secondary to multiple sclerosis. However, currently there are still no neuroprotective compounds registered and available in the clinic. We reviewed the literature supporting the retinoprotective properties of phenytoin and analyzed the various approaches and definitions from the first research periods onwards. The retinoprotective role of phenytoin was already known in the 1970s, but only recently has this effect been rediscovered, confirming that it could indeed provide structural protection of the retinal cells.

KEYWORDS:

multiple sclerosis; neuroprotection; optic neuritis; phenytoin; retinoprotection

PMID:
30410309
PMCID:
PMC6198895
DOI:
10.2147/DDDT.S169621
[Indexed for MEDLINE]
Free PMC Article

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