Format

Send to

Choose Destination
J Exp Med. 2018 Dec 3;215(12):2994-3005. doi: 10.1084/jem.20181206. Epub 2018 Nov 8.

Epidermal γδ T cells originate from yolk sac hematopoiesis and clonally self-renew in the adult.

Author information

1
Aix-Marseille University, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Centre d'Immunologie de Marseille-Luminy, Marseille, France.
2
Singapore Immunology Network, Agency for Science, Technology and Research, Singapore.
3
Institute of Pathology, Charité Universitätsmedizin Berlin, Berlin, Germany.
4
Shanghai Institute of Immunology, Shanghai JiaoTong University School of Medicine, Shanghai, China.
5
Aix-Marseille University, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Centre d'Immunologie de Marseille-Luminy, Marseille, France bajenoff@ciml.univ-mrs.fr.

Abstract

The murine epidermis harbors two immune cell lineages, Langerhans cells (LCs) and γδ T cells known as dendritic epidermal T cells (DETCs). LCs develop from both early yolk sac (YS) progenitors and fetal liver monocytes before locally self-renewing in the adult. For DETCs, the mechanisms of homeostatic maintenance and their hematopoietic origin are largely unknown. Here, we exploited multicolor fate mapping systems to reveal that DETCs slowly turn over at steady state. Like for LCs, homeostatic maintenance of DETCs is achieved by clonal expansion of tissue-resident cells assembled in proliferative units. The same mechanism, albeit accelerated, facilitates DETC replenishment upon injury. Hematopoietic lineage tracing uncovered that DETCs are established independently of definitive hematopoietic stem cells and instead originate from YS hematopoiesis, again reminiscent of LCs. DETCs thus resemble LCs concerning their maintenance, replenishment mechanisms, and hematopoietic development, suggesting that the epidermal microenvironment exerts a lineage-independent influence on the initial seeding and homeostatic maintenance of its resident immune cells.

PMID:
30409784
PMCID:
PMC6279412
[Available on 2019-06-03]
DOI:
10.1084/jem.20181206

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center