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Food Chem. 2019 Mar 15;276:376-382. doi: 10.1016/j.foodchem.2018.10.017. Epub 2018 Oct 4.

Antihypertensive effects of orally administered eggplant (Solanum melongena) rich in acetylcholine on spontaneously hypertensive rats.

Author information

1
Department of Agriculture, Graduate School of Science and Technology, Shinshu University, 8304, Minamiminowa, Nagano 399-4598, Japan.
2
Wellnas. Co., Ltd., 508-2, Fii Building, 3-15-1, Tokida, Ueda, Nagano 386-8567, Japan.
3
Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical University, Hebei 050017, China.
4
Department of Food, Life and Environmental Science, Faculty of Agriculture, Yamagata University, 1-23 Wakaba-machi, Tsuruoka, Yamagata 997-8555, Japan.
5
Kochi Agricultural Research Center, 1100 Hataeda, Nankoku, Kochi 783-0023, Japan.
6
Institute of Vegetable and Floriculture Science, NARO, 360 Kusawa, Ano-cho, Tsu, Mie 514-2392, Japan.
7
Department of Agriculture, Graduate School of Science and Technology, Shinshu University, 8304, Minamiminowa, Nagano 399-4598, Japan; Institute of Agriculture, Academic Assembly, Shinshu University, 8304, Minamiminowa, Nagano 399-4598, Japan. Electronic address: knakamu@shinshu-u.ac.jp.

Abstract

Our previous results (Nakamura et al., 2013, 2016) indicated that acetylcholine (ACh) in orally administered foods exerts antihypertensive effects. Eggplants (Solanum melongena) contain abundant ACh (Horiuchi et al., 2003), and their food functionality was discovered, using spontaneously hypertensive rats, by measuring blood pressure after oral administration of a suspension of lyophilized eggplant powder. We found that lyophilized eggplant powder induced significantly lowered acute and chronic blood pressure levels at very low doses of 0.0650 mg/kg body weight (b.w.) and 0.821 mg/(kg b.w.·day), respectively. Chronic administration suppressed adrenaline and noradrenaline excretion in the urine, and aorta assays showed that eggplant acted on the M3 muscarinic ACh receptor (M3 mAChR). ACh was conclusively shown to function as the main component of eggplant contributing to antihypertensive activity by suppressing sympathetic nervous activity via M3 mAChR. This report reveals a new food functionality of eggplant and its potential as a novel antihypertensive food.

KEYWORDS:

Acetylcholine; Blood pressure; Catecholamine; Eggplant; Spontaneously hypertensive rats

PMID:
30409608
DOI:
10.1016/j.foodchem.2018.10.017
[Indexed for MEDLINE]
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