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Appl Radiat Isot. 2019 Jan;143:107-112. doi: 10.1016/j.apradiso.2018.10.024. Epub 2018 Oct 26.

Evaluation of ions and metals in the blood of GRMD dogs submitted to hASCs therapy by NAA and XRF techniques.

Author information

1
Instituto de Pesquisas Energéticas e Nucleares, IPEN - CNEN/SP, Centro do Reator de Pesquisa - CRPq, Av. Professor Lineu Prestes 2242, 05508-000 São Paulo, SP, Brazil. Electronic address: metairon@live.com.
2
Instituto de Pesquisas Energéticas e Nucleares, IPEN - CNEN/SP, Centro do Reator de Pesquisa - CRPq, Av. Professor Lineu Prestes 2242, 05508-000 São Paulo, SP, Brazil. Electronic address: czamboni@ipen.br.
3
Instituto de Pesquisas Energéticas e Nucleares, IPEN - CNEN/SP, Centro do Reator de Pesquisa - CRPq, Av. Professor Lineu Prestes 2242, 05508-000 São Paulo, SP, Brazil. Electronic address: mfsuzuki@ipen.br.
4
Centro de Estudos do Genoma Humano, Instituto de Biociências, USP, Rua: do Matão, Travessa 13, 106, 05508-090 São Paulo, SP, Brazil. Electronic address: buenojr@usp.br.

Abstract

The elements Br, Ca, Cl, Cr, Fe, K, Mg, Na, P, Rb, S, and Zn were investigated in the whole blood samples of Golden Retriever dogs submitted to cell therapy (hASCs). These analyses were performed over 2 years using Neutron Activation Analysis and X-Ray Fluorescence techniques. The results were compared with control and untreated dog's. A significant increase was observed in K blood levels. There was also variation in blood levels of Br, Cr, Fe, Rb, S, and Zn.

KEYWORDS:

Blood analyses; Duchenne Muscular Dystrophy; Neutron Activation Analysis; X-ray fluorescence; hASCs therapy

PMID:
30408633
DOI:
10.1016/j.apradiso.2018.10.024
[Indexed for MEDLINE]

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