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PLoS One. 2018 Nov 8;13(11):e0206869. doi: 10.1371/journal.pone.0206869. eCollection 2018.

The common truncation variant in pancreatic lipase related protein 2 (PNLIPRP2) is expressed poorly and does not alter risk for chronic pancreatitis.

Author information

1
Center for Exocrine Disorders, Department of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, United States of America.
2
First Department of Medicine, University of Szeged, Szeged, Hungary.
3
Institute for Translational Medicine, University of Pécs, Pécs, Hungary.
4
First Department of Surgery, Semmelweis University, Budapest, Hungary.
5
First Department of Medicine, University of Pécs, Pécs, Hungary.
6
Department of Pediatrics, Washington University School of Medicine, St Louis, MO, United States of America.

Abstract

A nonsense variant (p.W358X) of human pancreatic lipase related protein 2 (PNLIPRP2) is present in different ethnic populations with a high allele frequency. In cell culture experiments, the truncated protein mainly accumulates inside the cells and causes endoplasmic reticulum stress. Here, we tested the hypothesis that variant p.W358X might increase risk for chronic pancreatitis through acinar cell stress. We sequenced exon 11 of PNLIPRP2 in a cohort of 256 subjects with chronic pancreatitis (152 alcoholic and 104 non-alcoholic) and 200 controls of Hungarian origin. We observed no significant difference in the distribution of the truncation variant between patients and controls. We analyzed mRNA expression in human pancreatic cDNA samples and found the variant allele markedly reduced. We conclude that the p.W358X truncation variant of PNLIPRP2 is expressed poorly and has no significant effect on the risk of chronic pancreatitis.

Conflict of interest statement

The authors have declared that no competing interests exist.

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