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Acta Ophthalmol. 2019 Jun;97(4):e519-e525. doi: 10.1111/aos.13970. Epub 2018 Nov 8.

Automatic computer-aided analysis of optic disc pallor in fundus photographs.

Author information

1
Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
2
Innovative Medical Engineering & Technology, Division of Convergence Technology, National Cancer Center, Goyang, Korea.
3
Department of Ophthalmology, Kangwon National University Hospital, Kangwon National University Graduate School of Medicine, Chuncheon, Korea.
4
Department of Biomedical Engineering, Gachon University College of Medicine, Incheon, Korea.

Abstract

PURPOSE:

Assessment of optic disc pallor in fundus photographs may be frequently misinterpreted due to the subjective nature of interpretation. We developed a fully automatic computer-aided detection (CAD) system for optic disc pallor using colour fundus photographs and evaluated the accuracy of the system.

METHODS:

A newly proposed CAD system was developed for automated segmentation and image analysis of optic disc pallor, and a logistic regression model was developed for risk analysis. A total of 230 photographs with variable degree of optic disc pallor, and 123 normal optic discs confirmed by optical coherence tomography were tested for validation of the software. Sensitivity and specificity of the CAD system in automatic detection of optic disc pallor using colour fundus photographs were evaluated. The results of manual detection of optic disc pallor on fundus photographs by two independent ophthalmologists were compared with the efficacy of the CAD system.

RESULTS:

The fully automated CAD system achieved a sensitivity of 95.3% and a specificity of 96.7% for detecting optic disc pallor in colour fundus images. The overall accuracy of the CAD system was 96.1%, which was superior to the results of manual detection by individual examiners.

CONCLUSIONS:

We developed an automated CAD system that successfully detected optic disc pallor in fundus photographs. The proposed algorithm can assist the clinical judgement of ophthalmologists for detecting optic disc pallor in fundus photographs.

KEYWORDS:

automatic; computer-aided detection; optic disc; pallor

PMID:
30407733
DOI:
10.1111/aos.13970
[Indexed for MEDLINE]

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