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Curr Neurol Neurosci Rep. 2018 Nov 8;18(12):106. doi: 10.1007/s11910-018-0908-5.

Untangling PTSD and TBI: Challenges and Strategies in Clinical Care and Research.

Author information

1
VISN 20 Northwest Network Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System, 1660 S. Columbian Way, S116 MIRECC, Seattle, WA, 98108, USA. rhend@uw.edu.
2
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, 1959 NE Pacific Street, Box 356560 Room BB1644, Seattle, WA, 98195-6560, USA. rhend@uw.edu.
3
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, 1959 NE Pacific Street, Box 356560 Room BB1644, Seattle, WA, 98195-6560, USA.
4
Geriatric Research, Education and Clinical Center (GRECC), VA Puget Sound Health Care System, 1660 S. Columbian Way, S116 MIRECC, Seattle, WA, 98108, USA.
5
VISN 20 Northwest Network Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System, 1660 S. Columbian Way, S116 MIRECC, Seattle, WA, 98108, USA.

Abstract

PURPOSE OF REVIEW:

Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) can result from similar injuries and can result in similar symptoms, such as problems with sleep, concentration, memory, and mood. Although PTSD and persistent sequelae due to a TBI (PST) have generally been viewed as pragmatically confounded but conceptually separable entities, we examine emerging evidence emphasizing the breadth of overlap in both clinical presentation and underlying pathophysiology between PST and PTSD.

RECENT FINDINGS:

New evidence underscores the poor specificity of symptoms to etiology and emphasizes the potential, after both physical brain injury and traumatic stress, for changes in each of the three interacting systems that coordinate the body's response to the experience or expectation of major injury-the immune, endocrine, and neuromodulatory neurotransmitter systems. A view of PTSD and PST sharing common pathophysiologic elements related to the CNS response to acute injury or threat carries important implications for research and clinical care.

KEYWORDS:

Catecholamines; Neuroinflammation; Pituitary; Post-traumatic stress disorder (PTSD); Trauma; Traumatic brain injury (TBI)

PMID:
30406855
DOI:
10.1007/s11910-018-0908-5
[Indexed for MEDLINE]

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