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Expert Rev Mol Diagn. 2018 Nov 8:1-12. doi: 10.1080/14737159.2018.1544494. [Epub ahead of print]

The potential of tumor-derived exosomes for noninvasive cancer monitoring: an update.

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1
a Departments of Pathology, Immunology and Otolaryngology , University of Pittsburgh School of Medicine and UPMC Hillman Cancer Center , Pittsburgh , PA , USA.

Abstract

Liquid biopsy platforms are being actively developed in the biomarker field. Extracellular vesicles (EVs), especially the tumor-derived exosome (TEX) subsets of EVs, represent a platform that allows for molecular and genetic profiling of parent tumor cells. TEX are ubiquitous in body fluids of cancer patients and are promising clinically relevant surrogates of cancer cells. Areas covered: Isolation from body fluids of cancer patients and subsetting of exosomes based on immunoaffinity capture offers a means of evaluating proteins, lipids, nucleic acids and other molecular contents that are a characteristic of TEX and exosomes produced by reprogrammed normal cells. The same liquid biopsy can inform about the status of a tumor and simultaneously evaluate the competency of immune cells to mediate anti-tumor activities. Expert commentary: TEX and reprogrammed non-TEX isolated from plasma of cancer patients have the potential to become non-invasive biomarkers of cancer diagnosis, prognosis and response to therapies.

KEYWORDS:

Extracellular vesicles; cancer; non-invasive biomarkers; tumor-derived exosomes

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