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Front Oncol. 2018 Oct 23;8:473. doi: 10.3389/fonc.2018.00473. eCollection 2018.

The Antitumor Activities of Marsdenia tenacissima.

Wang X1,2, Yan Y1,2, Chen X1,2, Zeng S1,2, Qian L1,2, Ren X3, Wei J1,2, Yang X1,2, Zhou Y4, Gong Z1,2, Xu Z5.

Author information

1
Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.
2
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
3
Key Laboratory of Molecular Radiation Oncology of Hunan Province, Center for Molecular Medicine, Xiangya Hospital, Central South University, Changsha, China.
4
Department of Oncology, Xiangya Hospital, Central South University, Changsha, China.
5
Department of Pathology, Xiangya Hospital, Central South University, Changsha, China.

Abstract

Marsdenia tenacissima (MT), a traditional Chinese herbal medicine, has long been used for thousands of years to treat asthma, tracheitis, rheumatism, etc. An increasing number of recent studies have focused on the antitumor effects of MT. The effects of MT on cancer are the result of various activated signaling pathways and inhibiting factors and the high expression levels of regulatory proteins. MT can inhibit different cancer types including non-small cell lung cancer (NSCLC), malignant tumors, hepatic carcinoma, and so on. This article mainly focuses on the activities and mechanisms of MT. In addition, the efficacy and toxicity of MT are also discussed. Further studies of MT are required for improved medicinal utilization.

KEYWORDS:

Marsdenia tenacissima; antitumor activities; efficacy; malignant tumor; signaling pathways; toxicity

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