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Pharmaceutics. 2018 Nov 6;10(4). pii: E218. doi: 10.3390/pharmaceutics10040218.

Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery.

Author information

1
Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Patras, 26504 Rio-Patras, Greece. santimis@upatras.gr.
2
Foundation for Research and Technology Hellas, Institute of Chemical Engineering, FORTH/ICE-HT, 26504 Rio-Patras, Greece. santimis@upatras.gr.
3
Foundation for Research and Technology Hellas, Institute of Chemical Engineering, FORTH/ICE-HT, 26504 Rio-Patras, Greece. mourtas@upatras.gr.
4
Foundation for Research and Technology Hellas, Institute of Chemical Engineering, FORTH/ICE-HT, 26504 Rio-Patras, Greece. amarazioti@upatras.gr.

Abstract

The similarities between exosomes and liposomes, together with the high organotropism of several types of exosomes, have recently prompted the development of engineered-exosomes or exosome-mimetics, which may be artificial (liposomal) or cell-derived vesicles, as advanced platforms for targeted drug delivery. Here, we provide the current state-of-the-art of using exosome or exosome-inspired systems for drug delivery. We review the various approaches investigated and the shortcomings of each approach. Finally the challenges which have been identified to date in this field are summarized.

KEYWORDS:

bioinspired systems; drug delivery; drug targeting; engineered systems; exosomes; extracellular vesicles; liposomes

PMID:
30404188
DOI:
10.3390/pharmaceutics10040218
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