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Nutrients. 2018 Nov 6;10(11). pii: E1691. doi: 10.3390/nu10111691.

A Distinct Pattern of Circulating Amino Acids Characterizes Older Persons with Physical Frailty and Sarcopenia: Results from the BIOSPHERE Study.

Author information

1
Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome 00168, Italy. riccardo.calvani@gmail.com.
2
Università Cattolica del Sacro Cuore, Rome 00168, Italy. riccardo.calvani@gmail.com.
3
Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome 00168, Italy. anna.picca1@gmail.com.
4
Università Cattolica del Sacro Cuore, Rome 00168, Italy. anna.picca1@gmail.com.
5
Department of Chemistry, Sapienza University of Rome, Rome 00168, Italy. federico.marini@uniroma1.it.
6
Department of Chemistry, Sapienza University of Rome, Rome 00168, Italy. alessandra.biancolillo@uniroma1.it.
7
Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome 00168, Italy. jacopo.gervasoni@policlinicogemelli.it.
8
Università Cattolica del Sacro Cuore, Rome 00168, Italy. jacopo.gervasoni@policlinicogemelli.it.
9
Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome 00168, Italy. silvia.persichilli@policlinicogemelli.it.
10
Università Cattolica del Sacro Cuore, Rome 00168, Italy. silvia.persichilli@policlinicogemelli.it.
11
Università Cattolica del Sacro Cuore, Rome 00168, Italy. anielloprim@gmail.com.
12
Università Cattolica del Sacro Cuore, Rome 00168, Italy. coelhojunior@hotmail.com.br.
13
Applied Kinesiology Laboratory⁻LCA, School of Physical Education, University of Campinas, Campinas-SP 13.083-851, Brazil. coelhojunior@hotmail.com.br.
14
Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome 00168, Italy. mauriziobossola@gmail.com.
15
Università Cattolica del Sacro Cuore, Rome 00168, Italy. mauriziobossola@gmail.com.
16
Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome 00168, Italy. andrea.urbani@unicatt.it.
17
Università Cattolica del Sacro Cuore, Rome 00168, Italy. andrea.urbani@unicatt.it.
18
Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome 00168, Italy. francesco.landi@unicatt.it.
19
Università Cattolica del Sacro Cuore, Rome 00168, Italy. francesco.landi@unicatt.it.
20
Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome 00168, Italy. roberto.bernabei@unicatt.it.
21
Università Cattolica del Sacro Cuore, Rome 00168, Italy. roberto.bernabei@unicatt.it.
22
Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome 00168, Italy. emanuele.marzetti@policlinicogemelli.it.

Abstract

Physical frailty and sarcopenia (PF&S) are hallmarks of aging that share a common pathogenic background. Perturbations in protein/amino acid metabolism may play a role in the development of PF&S. In this initial report, 68 community-dwellers aged 70 years and older, 38 with PF&S and 30 non-sarcopenic, non-frail controls (nonPF&S), were enrolled as part as the "BIOmarkers associated with Sarcopenia and Physical frailty in EldeRly pErsons" (BIOSPHERE) study. A panel of 37 serum amino acids and derivatives was assayed by UPLC-MS. Partial Least Squares⁻Discriminant Analysis (PLS-DA) was used to characterize the amino acid profile of PF&S. The optimal complexity of the PLS-DA model was found to be three latent variables. The proportion of correct classification was 76.6 ± 3.9% (75.1 ± 4.6% for enrollees with PF&S; 78.5 ± 6.0% for nonPF&S). Older adults with PF&S were characterized by higher levels of asparagine, aspartic acid, citrulline, ethanolamine, glutamic acid, sarcosine, and taurine. The profile of nonPF&S participants was defined by higher concentrations of α-aminobutyric acid and methionine. Distinct profiles of circulating amino acids and derivatives characterize older people with PF&S. The dissection of these patterns may provide novel insights into the role played by protein/amino acid perturbations in the disabling cascade and possible new targets for interventions.

KEYWORDS:

aging; biomarkers; metabolism; metabolomics; multi-marker; multivariate; muscle; physical performance; profiling; protein

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