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Am J Public Health. 2018 Dec;108(12):1695-1706. doi: 10.2105/AJPH.2018.304696.

Multicomponent Obesity Prevention Intervention in Low-Income Preschoolers: Primary and Subgroup Analyses of the NET-Works Randomized Clinical Trial, 2012-2017.

Author information

Simone A. French, Nancy E. Sherwood, Nathan R. Mitchell, and Anne Marie Hotop are with Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis. Sara Veblen-Mortenson is with Office of the Dean, School of Public Health, University of Minnesota. A. Lauren Crain is with HealthPartners Institute, Minneapolis. At the time of study, Meghan M. JaKa was with Washington, DC, Department of Health. Jerica M. Berge is with the Department of Family Medicine and Community Health, University of Minnesota. Alicia S. Kunin Batson is with the Department of Pediatrics, University of Minnesota. Kim Truesdale and June Stevens are with the University of North Carolina, Chapel Hill. Charlotte Pratt is with the National Heart, Lung, and Blood Institute, Bethesda, MD. Layla Esposito is with the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda.



To evaluate a multicomponent obesity prevention intervention among diverse, low-income preschoolers.


Parent-child dyads (n = 534) were randomized to the Now Everybody Together for Amazing and Healthful Kids (NET-Works) intervention or usual care in Minneapolis, MN (2012-2017). The intervention consisted of home visits, parenting classes, and telephone check-ins. The primary outcomes were adjusted 24- and 36-month body mass index (BMI).


Compared with usual care, the NET-Works intervention showed no significant difference in BMI change at 24 (-0.12 kg/m2; 95% confidence interval [CI] = -0.44, 0.19) or 36 months (-0.19 kg/m2; 95% CI = -0.64, 0.26). Energy intake was significantly lower in the NET-Works group at 24 (-90 kcal/day; 95% CI = -164, -16) and 36 months (-101 kcal/day; 95% CI = -164, -37). Television viewing was significantly lower in the NET-Works group at 24 (rate ratio = 0.84; 95% CI = 0.75, 0.93) and 36 months (rate ratio = 0.88; 95% CI = 0.78, 0.99). Children with baseline overweight or obesity had lower BMI in the NET-Works group than those in usual care at 36 months (-0.71 kg/m2; 95% CI = -1.30, -0.12). Hispanic children had lower BMI in the NET-Works group than those in usual care at 36 months (-0.59 kg/m2; 95% CI = -1.14, -0.04).


In secondary analyses, NET-Works significantly reduced BMI over 3 years among Hispanic children and children with baseline overweight or obesity.

TRIAL REGISTRATION: Identifier: NCT01606891.

[Available on 2019-12-01]
[Indexed for MEDLINE]

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