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Folia Morphol (Warsz). 2018 Nov 7. doi: 10.5603/FM.a2018.0050. [Epub ahead of print]

Neuroprotective effects of Potentilla fulgens on spinal cord injury in rats: an immunohistochemical analysis.

Author information

1
Department of Anatomy, Faculty of Medicine, University of Dicle, 21280 Diyarbakır, Turkey. drcudi@hotmail.com.

Abstract

This examination was performed to research the advantage of the antioxidant impact of Potentilla fulgens on spinal cord injury (SCI) in rats. In the SCI model of this examination, the tolerably serious lesion was performed at the L1-L2 spinal segmental level. Spinal cord injury animals were given P. fulgens 400 mg/kg/day, intraperitoneally. At seven days post-lesion, exploratory rats were executed after intraperitoneal administration of ketamine HCL (0.15 ml/100 g body weight). Spinal cord specimens were taken for histological examination or assurance of malondialdehyde (MDA) and glutathione (GSH) levels and myeloperoxidase (MPO) action. SCI caused a remarkable decline in spinal cord GSH content, trailed by noteworthy increments in MDA levels and MPO action. Degenerative changes in some multipolar and bipolar nerve cells and picnotic changes in the nuclei of glial cells were likewise noticed. Remarkable development was seen in cells and vascular structures of P. fulgens treated groups when contrasted with untreated groups. P. fulgens application may influence angiogenetic improvement in vein endothelial cells, reduce inflammatory cell aggregation by influencing cytokine system and may make apoptotic nerve cells and neuroprotective component in glial cells.

KEYWORDS:

Bcl-2 (B-cell lymphoma 2); Potentilla fulgens; Spinal cord injury; VEGF

PMID:
30402877
DOI:
10.5603/FM.a2018.0050
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