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Case Rep Oncol Med. 2018 Oct 3;2018:8460603. doi: 10.1155/2018/8460603. eCollection 2018.

Malignant Transformation of Testicular Teratoma to PNET, Adenocarcinoma, and Osteosarcoma with Complete Remission after Surgery and Combination Chemotherapy in a Young Adult Male.

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1
Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
2
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
3
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Abstract

Mixed germ cell tumors (GCT) with teratoma components can transform into somatic malignancies which can include histologies outside of traditional germ cell lineages. We describe a case of an 18-year-old man with a metastatic testicular GCT with both mature and immature teratoma components containing malignant transformation into multiple histologies including PNET in the primary testicular tumor and osteosarcoma in a separate pulmonary metastatic lesion. Management with targeted chemotherapy resulted in a durable remission. This is the first reported case that we know of a patient with primary PNET malignant transformation with subsequent metastatic transformation to osteosarcoma.

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