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Nat Med. 2018 Nov;24(11):1645-1648. doi: 10.1038/s41591-018-0250-0. Epub 2018 Nov 6.

Is earlier better for melanoma checkpoint blockade?

Author information

1
Paris-Sud University, Kremlin-BicĂȘtre, France. caroline.robert@gustaveroussy.fr.
2
Oncology Department and INSERM U981, Villejuf, France. caroline.robert@gustaveroussy.fr.

Abstract

A neoadjuvant approach relying on the administration of combined anti-CTLA-4-anti-PD-1 treatment before lymph node surgery is evaluated in two phase 1 trials. Encouraging clinical, pathological and immunological responses to neoadjuvant therapy were observed, suggesting that this concept warrants further exploration; however, any future approach must address the unacceptably high toxicity of the regimens evaluated in these trials.

PMID:
30401867
DOI:
10.1038/s41591-018-0250-0
[Indexed for MEDLINE]

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