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Biosci Rep. 2018 Nov 6. pii: BSR20181857. doi: 10.1042/BSR20181857. [Epub ahead of print]

Dietary protein intake and risk of ovarian cancer: Evidence from a meta-analysis of observational studies.

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Hainan Medical University, No. 3, Xueyuan Road, Haikou, China.
Hainan Medical University, No. 3, Xueyuan Road, Haikou, China


The association between dietary protein intake and ovarian cancer had been inconsistent in the previous epidemiological studies. The aim of this study was to identify and synthesize all citations evaluating the relationship on ovarian cancer with protein intake. The search included PubMed, Embase, and Web of Science from inception to June 2018. Two authors independently selected studies, extracted data and assessed risk of bias. RR and 95%CI were calculated for relationship between the dietary protein intake and ovarian cancer risk using a random-effects model. Publication bias was evaluated using Egger's test and Begg's funnel plots. At the end, ten citations with 2354 patients were included in meta-analysis. Summarized relative risk (RR) with 95% confidence interval (95%CI) on ovarian cancer was 0.915 (95%CI= 0.821-1.021), with no between-study heterogeneity ( I 2= 0.0%, P = 0.708). The results were consistent both in animal protein intake and in vegetable intake on ovarian cancer. Subgroup analysis by study design did not find positive association either in cohort studies or in case-control studies. Egger's test ( P = 0.230) and Funnel plot suggested no publication bias. Based on the obtained results, we conclude that high dietary protein intake had no significant association on ovarian cancer risk. Besides that, it is necessary to develop high-quality, large scale studies with detailed amount of dietary protein intake for verifying our results.


Meta-analysis; Ovarian cancer; Protein intake


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