Format

Send to

Choose Destination
Eur J Intern Med. 2018 Nov 3. pii: S0953-6205(18)30413-8. doi: 10.1016/j.ejim.2018.10.020. [Epub ahead of print]

An international perspective on hospitalized patients with viral community-acquired pneumonia.

Radovanovic D1, Sotgiu G2, Jankovic M3, Mahesh PA4, Marcos PJ5, Abdalla MI6, Di Pasquale MF7, Gramegna A7, Terraneo S8, Blasi F7, Santus P1, Aliberti S9, Reyes LF10, Restrepo MI6; GLIMP Study Group, Aruj PK11, Attorri S12, Barimboim E13, Caeiro JP14, Garzón MI14, Cambursano VH15, Ceccato A16, Chertcoff J17, Cordon Díaz A18, de Vedia L19, Ganaha MC20, Lambert S21, Lopardo G22, Luna CM23, Malberti AG24, Morcillo N25, Tartara S25, Pensotti C26, Pereyra B27, Scapellato PG28, Stagnaro JP29, Shah S30, Lötsch F31, Thalhammer F31, Anseeuw K32, Francois CA33, Van Braeckel E34, Vincent JL35, Djimon MZ36, Aranha Nouér S37, Chipev P38, Encheva M38, Miteva D39, Petkova D40, Balkissou AD41, Pefura Yone EW42, Mbatchou Ngahane BH43, Shen N44, Xu JF45, Bustamante Rico CA46, Buitrago R46, Pereira Paternina FJ47, Kayembe Ntumba JM48, Vladic-Carevic V49, Jakopovic M50, Matkovic Z51, Mitrecic I52, Bouchy Jacobsson ML53, Bro Christensen A54, Heitmann Bødtger UC55, Meyer CN56, Vestergaard Jensen A57, El-Said Abd El-Wahhab I58, Elsayed Morsy N59, Shafiek H60, Sobh E61, Abdulsemed KA62, Bertrand F63, Brun-Buisson C64, de Montmollin E65, Fartoukh M66, Messika J67, Tattevin P68, Khoury A69, Ebruke B70, Dreher M71, Kolditz M72, Meisinger M73, Pletz MW74, Hagel S74, Rupp J75, Schaberg T76, Spielmanns M77, Creutz P78, Suttorp N78, Siaw-Lartey B79, Dimakou K80, Papapetrou D81, Tsigou E82, Ampazis D82, Kaimakamis E83, Bhatia M84, Dhar R85, D'Souza G86, Garg R87, Koul PA88, Jayaraj BS89, Narayan KV90, Udnur HB91, Krishnamurthy SB91, Kant S92, Swarnakar R93, Salvi S94, Limaye S94, Golshani K95, Keatings VM96, Martin-Loeches I97, Maor Y98, Strahilevitz J99, Battaglia S100, Carrabba M101, Ceriana P102, Confalonieri M103, d'Arminio Monforte A104, Del Prato B105, De Rosa M106, Fantini R107, Fiorentino G108, Gammino MA109, Menzella F110, Milani G111, Nava S112, Palmiero G113, Petrino R114, Gabrielli B114, Rossi P115, Sorino C116, Steinhilber G117, Zanforlin A118, Franzetti F119, Carone M120, Patella V121, Scarlata S122, Comel A123, Kurahashi K124, Aoun Bacha Z125, Barajas Ugalde D126, Ceballos Zuñiga O127, Villegas JF128, Medenica M129, van de Garde EMW130, Raj Mihsra D131, Shrestha P132, Ridgeon E133, Ishola Awokola B134, Nwankwo ONO135, Olufunlola AB136, Olumide S137, Ukwaja KN138, Irfan M139, Minarowski L140, Szymon S141, Froes F142, Leuschner P143, Meireles M144, Ferrão C144, Leuschner P144, Neves J144, Ravara SB145, Brocovschii V146, Ion C147, Rusu D148, Toma C149, Chirita D150, Dorobat CM151, Birkun A152, Kaluzhenina A153, Almotairi A154, Bukhary ZAA155, Edathodu J156, Fathy A157, Mushira Abdulaziz Enani A158, Eltayeb Mohamed N158, Ulhadi Memon J159, Bella A160, Bogdanović N161, Milenkovic B162, Pesut D163, Borderìas L164, Bordon Garcia NM165, Cabello Alarcón H166, Cilloniz C167, Torres A167, Diaz-Brito V167, Casas X167, Encabo González A168, Fernández-Almira ML169, Gallego M170, Gaspar-GarcÍa I171, González Del Castillo J172, Javaloyes Victoria P173, Laserna Martínez E174, Malo de Molina R175, Menéndez R176, Pando-Sandoval A177, Prat Aymerich C178, Lacoma de la Torre A178, García-Olivé I178, Rello J179, Moyano S179, Sanz F180, Sibila O181, Rodrigo-Troyano A181, Solé-Violán J182, Uranga A183, van Boven JFM184, Vendrell Torra E185, Pujol JA185, Feldman C186, Kee Yum H187, Fiogbe AA188, Yangui F189, Bilaceroglu S190, Dalar L191, Yilmaz U192, Bogomolov A193, Elahi N194, Dhasmana DJ195, Feneley A196, Hancock C197, Hill AT198, Rudran B199, Ruiz-Buitrago S200, Campbell M200, Whitaker P201, Youzguin A202, Singanayagam A203, Allen KS204, Brito V205, Dietz J206, Dysart CE207, Kellie SM207, Franco-Sadud RA208, Meier G208, Gaga M209, Holland TL210, Bergin SP210, Kheir F211, Landmeier M212, Lois M213, Nair GB214, Patel H215, Reyes K216, Rodriguez-Cintron W217, Saito S218, Soni NJ219, Noda J219, Hinojosa CI219, Levine SM219, Angel LF219, Anzueto A219, Scott Whitlow K220, Hipskind J220, Sukhija K220, Totten V220, Wunderink RG221, Shah RD221, Mateyo KJ222, Carugati M119, Morosi M119, Monge E119.

Author information

1
Department of Biomedical and Clinical Sciences (DIBIC), University of Milan, Section of Respiratory Diseases, Ospedale L. Sacco, ASST Fatebenefratelli-Sacco, Milan, Italy.
2
Clinical Epidemiology and Medical Statistics Unit, Department of Medical, Surgical and Experimental Medicine, University of Sassari, Sassari, Italy.
3
School of Medicine, University of Zagreb, Department for Respiratory Diseases Jordanovac, University Hospital Centre Zagreb, Croatia.
4
Department of Pulmonary Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, India.
5
Dirección de Procesos Asistenciales, Servicio de Neumología, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complejo Hospitalario Universitario de A Coruña (CHUAC), Estructura Organizativa de Xestion Integrada (EOXI) de A Coruña, SERGAS, Universidade da Coruña (UDC), A Coruña, Spain.
6
South Texas Veterans Health Care System and University of Texas Health, San Antonio, TX, USA.
7
Department of Pathophysiology and Transplantation, University of Milan, Internal Medicine Department, Respiratory Unit and Cystic Fibrosis Adult Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
8
Department of Health Sciences, University of Milan, Milan, Italy; Department of Health Sciences, University of Milan, Respiratory Unit, San Paolo Hospital, Milan, Italy.
9
Department of Pathophysiology and Transplantation, University of Milan, Internal Medicine Department, Respiratory Unit and Cystic Fibrosis Adult Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Electronic address: stefano.aliberti@unimi.it.
10
Department of Microbiology, Universidad de La Sabana, Chia, Colombia.
11
Department of Internal Medicine, University Hospital Alfredo Lanari, Buenos Aires, Argentina.
12
Hospital Luis Lago maggiore, Mendoza, Argentina.
13
Hospital Central de Mendoza, Argentina.
14
Hospital Privado Universitario, Córdoba, Argentina.
15
V.H. Dr Cazaux A. Servicio de Neumologia, Hospital Rawson, Córdoba, Argentina.
16
Hospital Nacional Prof Alejandro Posadas, Argentina.
17
Florencia Lascar and Fernando Di Tulio, Critical Care Unit and Respiratory Medicine, Buenos Aires British Hospital, Buenos Aires, Argentina.
18
Hospital General Alvear, Ciudad, Mendoza, Argentina.
19
Respiratory Intensive Care Unit, Hospital Muñiz, Buenos Aires, Argentina.
20
Infectious Diseases Ward, Hospital Interzonal General de Agudos "Vicente Lopez y Planes" from General Rodriguez, Buenos Aires, Argentina.
21
Hospital El Cruce - Alta Complejidad en Red, Argentina.
22
Hospital Bernardo Houssay, Vicente López, Argentina.
23
Pulmonary Medicine Division, Department of Medicine, Hospital de Clínicas, Universidad de Buenos Aires, Argentina.
24
Hospital Nuestra Señora del Carmen, Argentina.
25
Hospital Zonal Especializado de Agudos y Crónicos Dr. Antonio A. Cetrangolo, Argentina.
26
Infectious Diseases and Infection Control Department, Buenos Aires, Clinica Privada Monte Grande, Argentina.
27
Hospital San Roque, Córdoba, Argentina.
28
Infectious Diseases Department, Hospital D.F. Santojanni, Argentina.
29
HZGA Mi Pueblo, Florencio Varela, Argentina.
30
Department of General medicine, Austin hospital, Heidelberg, Australia.
31
Division of Infectious Diseases and Tropical Medicine, Department of Medicine I, Medical University of Vienna, Austria.
32
ZNA Campus Stuivenberg, Antwerp, Belgium.
33
Anesthesia and critical care department, Erasme university hospital, Brussels, Belgium.
34
Department of Respiratory Medicine, Ghent University Hospital, Belgium.
35
Department of Intensive Care, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium.
36
Jules Bashi and Roger Dodo, Centre Hospitalier Universitaire HKM of Cotonou, Benin.
37
Federal University of Rio de Janeiro, Brazil.
38
Clinic of Pulmonary Diseases, Military Medical Academy, Sofia, Bulgaria.
39
UMHAT "St. Marina", Varna, Bulgaria.
40
University Hospital Varna, Bulgaria.
41
Yaounde Jamot Hospital, Yaounde, Cameroon.
42
Département de Médecine Interne, University of Yaounde, Yaoundé, Cameroon.
43
Douala General Hospital, Douala, Cameroon.
44
Respiratory Medicine, Peking University Third Hospital, Beijing, China.
45
Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, China.
46
Clinica Shaio, Bogota, Colombia.
47
Las Americas Clinic, Medellin, Colombia.
48
Cliniques Universitaires de Kinshasa, DR, Congo.
49
Interne Medicine, Dubrovnik, Croatia.
50
Medical School, University of Zagreb, Department for Respiratory Diseases Jordanovac, University Hospital Centre Zagreb, Zagreb, Croatia.
51
University Hospital Dubrava, Zagreb, Croatia.
52
Karlovac general hospital, Karlovac, Croatia.
53
Emergency Department in North Zealand´s Hospital -, Hillerød, Denmark.
54
Department of Anaethesiology, Viborg Region Hospital, Denmark.
55
Department of Pulmonology, Naestved Hospital, Denmark.
56
Department of Internal Medicine, Roskilde Hospital, Copenhagen University Hospital, Roskilde, Denmark.
57
Gertrud Baunbæk-knudsen, Pelle Trier Petersen and Stine Andersen, Department of Lung- and Infectious Diseases, Nordsjællands Hospital-Hillerød, Denmark.
58
Thoracic Medicine, Faculty of Medicine, Mansoura University, Egypt.
59
Pulmonary, Critical Care and Sleep Medicine, Mansoura University, Mansoura, Egypt.
60
Chest diseases department, Alexandria University, Egypt.
61
Chest Diseases Department, Al-Azhar University, Cairo, Egypt.
62
Department of Medical Laboratory Science and Pathology, College of Health sciences, Mycobacteriology Research Centre, Institute of Biotechnology Research, Jimma University, Jimma, Ethiopia.
63
Critical care Unit, Robert Ballanger Hospital, Aulnay sous Bois, France.
64
Univ Hospital Henri Mondor, 94000 Créteil, France.
65
Intensive care unit, Hôpital Delafontaine, Centre hospitalier de Saint-Denis, Saint-Denis, France.
66
Unité de réanimation médico-chirurgicale, Pôle Thorax Voies aériennes, Hôpital Tenon, Groupe Hospitalier Est Parisien, France.
67
Publique-Hôpital de Paris, Service de Réanimation Médico-chirurgicale, Hôpital Louis Mourier, Colombes, France, and Université Paris Diderot, IAME, UMR 1137, Sorbonne Paris Cité, Paris, France.
68
Infectious Diseases & ICU, Pontchaillou University Hospital, Rennes, France.
69
Department of Emergency Medicine & Critical Care, University of Franche - Comté, Medical Center, France.
70
Medical Research Council Unit, Gambia.
71
Department of Cardiology, Pneumology, Vascular Medicine and Intensive Care Medicine, University Hospital Aachen, Aachen, Germany.
72
Division of Pulmonology, Medical Department I, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany.
73
Klinikum Niederlausitz GmbH, Klinik für Innere Medizin und Intensivmedizin, Senftenberg, Germany.
74
Center for Infectious Diseases and Infection Control, Jena University Hospital, Germany.
75
Department of Molecular and Infectious Diseases, University of Lübeck, Lübeck, Germany.
76
Zentrum für Pneumologie, Agaplesion Diakonieklinikum Rotenburg, Germany.
77
Internal Medicine Department, Pulmonary rehabilitation and Department of Health, School of Medicine, University Witten-Herdecke, St.Remigius-Hospital, Leverkusen, Germany.
78
Department of Infectious Disease and Respiratory Medicine, Charité - University Medicine, Berlin, Germany.
79
Komfo-Anokye Teaching Hospital, Kumasi, Ghana.
80
5th Respiratory Medicine Dpt, ''SOTIRIA" Chest Hospital, Athens 11527, Greece.
81
Medical Group of Athens (Paleo Faliro Clinic), Athens, Greece.
82
Agioi Anargiroi Hospital, Kifissia, Athens, Greece.
83
Intensive Care Unit, "G. Papanikolaou" General Hospital of Thessaloniki, Greece.
84
S.S. Hospital IMS BHU, Varanasi, India.
85
Fortis Hospitals, Kolkata, India.
86
Department of Pulmonary Medicine, St. John's Medical College Hospital, Bangalore 560034, India.
87
Department of Respiratory Medicine, King George's Medical University UP, Lucknow, India.
88
Department of Internal & Pulmonary Medicine, SheriKashmir Institute of Medical Sciences, Srinagar, India.
89
Department of Pulmonary Medicine, JSS Medical College, JSS University, Mysore, India.
90
Pulmonary Medicine, Government Medical College Kozhikode, Kerala, India.
91
Columbia Asia Hospital, Hebbal, Bengaluru, Karnataka, India.
92
Department of Respiratory Medicine, King George's Medical University, Chowk, Lucknow 226003, Uttar Pradesh, India.
93
Getwell Hospital & Research Institute, Dhantoli, Nagpur, India.
94
on behalf of the Respiratory Research Network of India (RRNI) from the Chest Research Foundation in Pune, India.
95
Isfahan University of Medical Sciences, Iran.
96
Letterkenny General Hospital, Co. Donegal, Ireland.
97
Multidisciplinary Intensive Care Research Organization (MICRO), St James's University Hospital, Trinity Centre for Health Sciences Dublin, Ireland.
98
Infectious Disease Unit, Affiliated to Tel Aviv University, Wolfson Medical Center, Holon, Israel.
99
Department of Clinical Microbiology & Infectious Diseases, Hadassah-Hebrew University, Jerusalem, Israel.
100
University of Palermo, Pneumologia DiBiMIS, Palermo, Italy.
101
Internal Medicine Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milano, Italy.
102
Pulmonary rehabilitation, IRCCS Fondazione Maugeri, 27100 Pavia, Italy.
103
Department of Pulmunology, University Hospital, Trieste, Italy.
104
Department of Health Sciences, Clinic of Infectious Disease, San Paolo Hospital, University of Milan, Italy.
105
Interventional Pneumology, Hospital Antonio Cardarelli, Naples, Italy.
106
UOC Pneumologia P.O. San Filippo Neri ASL RM E Roma, Italy.
107
Respiratory Diseases clinic, Policlinico di Modena, 41124 Modena, Italy.
108
UOC Fisiopatologia e Riabilitazione Respiratoria AO Ospedali dei Colli PO Monaldi, Italy.
109
Pulmonary Medicine Unit, San Martino Hospital, ASL 5 Oristano, Sardegna, Italy.
110
Department of Cardiac-Thoracic-Vascular and Intensive Care Medicine, Pneumology Unit, IRCCS- Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
111
Azienda Ospedaliera Sant Anna di Como, Presidio Ospedale S. Anna Nuovo, Unità Operativa di Pneumologia, Como, Italy.
112
Alma Mater University of Bologna, DIMES, Respiratory and Critical Care Unit Sant'Orsola Malpighi Hospital, Italy.
113
Respiratory Unit, Versilia Hospital, Azienda USL 12 Viareggio, Lido di Camaiore, Lucca, Italy.
114
Emergency Medicine Unit, S. Andrea Hospital, Vercelli, Italy.
115
Internal Medicine Department, Azienda Ospedaliero-Universitaria S. Maria della Misericordia, Udine, Italy.
116
Pulmonology Unit, A.O. Sant'Anna di Como, Italy.
117
Spedali Civili Brescia, U.O. Pneumologia e Fisiopatologia Respiratoria, Brescia, Italy.
118
ULSS 18 Rovigo, Ospedale San Luca, 45027 Trecenta (RO), Italy.
119
Department of Biomedical and Clinical Sciences, Division of Infectious Diseases, Luigi Sacco Hospital, Università degli Studi di Milano, Milan, Italy.
120
Fondazione Salvatore Maugeri, IRCCS, Cassano Murge, Italy.
121
Allergology and Clinical Immunology Unit, Department of Medical Sciences, Battipaglia Hospital, Battipaglia, Salerno, Italy.
122
Geriatrics, Unit of Respiratory Pathophysiology and Thoracic Endoscopy, Campus Bio Medico University and Teaching Hospital, Rome, Italy.
123
UO Pneumologia, Ospedale Pederzoli, Peschiera del Garda, Italy.
124
Yokohama City University Medical Center, Japan.
125
Medicine school, St Joseph University, Beyrouth, Lebanon.
126
National Institute of Respiratory Diseases, Mexico.
127
Hospital General de Mexicali, Mexicali, Baja California, Mexico.
128
Hospital Universitario Monterrey, n. l. México CP 64030, Mexico.
129
Hospital for Lung Diseases - Brezovik, Niksic, Montenegro.
130
Dept. Clinical Pharmacy, St. Antonius Hospital, Utrecht/Nieuwegein, The Netherlands.
131
Internal Medicine, BP Koirala Institute of Health Sciences, Nepal.
132
Oxford University Clinical Research Unit, Patan Hospital, Nepal.
133
Medical Research Institute of New Zealand, New Zealand.
134
Department of Family Medicine & Primary Care, Lily Hospitals Limited, Warri, Nigeria.
135
University of Calabar Teaching Hospital, Calabar, Nigeria.
136
Olabisi Onabanjo University teaching hospital, Sagamu, Ogun State, Nigeria.
137
Department of Medicine (Pulmonary Unit), University College Hospital, Ibadan, Nigeria.
138
Department of Medicine, Federal Teaching Hospital Abakaliki, Ebonyi State, Nigeria.
139
Section of Pulmonary and Critical Care Medicine, Department of Medicine, Aga Khan University, Karachi 74800, Pakistan.
140
Department of Lung Diseases and Tuberculosis, Medical University of Bialystok, Poland.
141
Department of Pneumology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Institute of Occupational Medicine and Environmental Health, Sosnowiec, Poland.
142
Hospital Pulido Valente - CHLN, Lisboa, Portugal.
143
Centro Hospitalar do Porto, Porto, Portugal.
144
Serviço de Medicina, Centro Hospitalar do Porto, Largo Prof. Abel Salazar, 4099-001 Porto, Portugal.
145
Faculty of Health Sciences, University of Beira Interior; Cova da Beira Hospital Center, 6200-251 Covilhã, Portugal.
146
Department of Pneumology & Allergology, State University of Medicine and Pharmacy "Nicolae Testemitanu", Moldavia.
147
Clinic of Anesthesia and Intensive Care "Valeriu Ghrerg", Institute of Emergency Medicine, State University of Medicine and Pharmacy "Nicolae Testemitanu", Chisinau, Moldavia.
148
SMFU "N.Testemitanu", Chisinau, Moldavia.
149
Department of Pneumology & Allergology, State University of Medicine and Pharmacy "Nicolae Testemitanu", Chisinau, Moldavia.
150
Hospital Sfantul Stefan, Bucharest, Romania.
151
Universitatea de Medicină şi Farmacie "Gr. T. Popa" I a ş i Facultatea de Medicină Stomatologică, Spitalul Clinic de Boli Infecţioase "Sfânta Parascheva" I a ş i str. Octav Botez, nr. 2, 700116 Iaşi, Romania.
152
Department of Anesthesiology, Critical Care and Emergency Medicine, Medical Academy named after S. I. Georgievsky, Russia.
153
Volgograd State Medical University, Russia.
154
King Fahad medical City (KFMC), Riyadh, Saudi Arabia.
155
College of Medicine, Taibah University, Medina, Saudi Arabia.
156
Al Faisal University, King Faisal Specialist Hospital, Riyadh, Saudi Arabia.
157
Pulmonary and respiratory critical care Medicine, Mansoura University Egypt, Affiliate at Taibah University, Saudi Arabia.
158
Infectious Diseases Section, Medical Specialties Department, King Fahad Medical City, Riyadh, Saudi Arabia.
159
Pulmonology Division, Department of Internal Medicine, King Fahad Hospital, Hofuf, Al Ahasa, 31982, Saudi Arabia.
160
Dammam University-Saudi Arabia and King Fahad Hospital, Saudi Arabia.
161
Pulmonary department of KHC Dr.Dragiša Mišović, Belgrade, Serbia.
162
Clinic for Pulmonary Diseases, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
163
University of Belgrade School of Medicine, Teaching Hospital of Pulmonology, Clinical Centre of Serbia, Belgrade, Serbia.
164
Respiratory and Sleep Unit, Hospital San Jorge, Huesca, Spain.
165
Barcelona Policlínic and Moises Broggi Hospital at sant Joan Despí, Spain.
166
Sant Hospital Seu de Urgell, Catalonia, Spain.
167
Department of Pneumology, Institut Clinic del Tórax, Hospital Clinic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona (UB), Spain.
168
Hospital Complex of Pontevedra, Spain.
169
Medicina Interna, Hospital Universitario Central de Asturias, Spain.
170
Department of Respiratory Medicine, Hospital de Sabadell, Institut Universitari Parc Taulí-UAB, Sabadell, Spain; CIBER de Enfermedades Respiratorias, CIBERES, Bunyola, Spain.
171
Department of Respiratory Medicine, Hospital Costa del Sol, Marbella, Málaga, Spain.
172
Emergency Department, Hospital Universitario Clínico San Carlos, Madrid, Spain.
173
Hospital General Universitario de Alicante, Alicante, Spain.
174
Hospital Mollet, Barcelona, Spain.
175
University Hospital Puerta de Hierro Majadahonda, Madrid.
176
Pneumology Service, Universitary and Polytechnic Hospital La Fe, Valencia, Spain.
177
Hospital Universitario Central de Asturias, Area de Gestion Clinica de Pulmon. Servicio de Neumologia, Oviedo, Spain.
178
Microbiology Department and Pneumology Department, Hospital Universitari Germans Trias i Pujol, Institut d'Investigació Germans Trias i Pujol, Badalona, Spain; Universitat Autònoma de Barcelona, CIBER Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Spain.
179
Critical Care Department, Hospital Vall d'Hebron, Barcelona, Spain.
180
Servicio de Neumología, Consorci Hospital General Universitari de Valencia, Valencia, Spain.
181
Servei de Pneumologia, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain.
182
Hospital Universitario de Gran Canaria Dr Negrín, Las Palmas de Gran Canaria, Spain.
183
Pulmology Department, Hospital of Galdakao-Usansolo, Spain.
184
Hospital Universitari Son Espases, Palma de Mallorca, Spain.
185
Intensive Care Medicine, Hospital de Mataró, Spain.
186
Division of Pulmonology, Department of Internal Medicine, Charlotte Maxeke Johannesburg Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
187
Inje Univ. Seoul Paik Hospital, South Korea.
188
Pulmonology and Infectious Diseases Service/University hospital of Sylvanus Olympio, Lomé, Togo.
189
Department of Pneumology, Hospital of Internal Forces Security (I.F.S), Marsa, Tunis, Tunisia.
190
Izmir Dr. Suat Seren Training and Research Hospital for Thoracic Medicine and Surgery, Izmir, Turkiye.
191
Pulmonary Medicine, Istanbul Bilim University, Istanbul, Turkiye.
192
Suat Seren Chest Disease and Surgery Training and Research Hospital, İzmir, Turkiye.
193
Vinnitsa National Pirogov Memorial Medical University, Vinnitsa regional antituberculosis hospital, Vinnitsa, Ukraine.
194
Dubai Hospital, United Arab Emirates.
195
Victoria Hospital, Kirkcaldy, NHS Fife, UK.
196
Rhiannon Ions, Julie Skeemer and Gerrit Woltmann, University Hospitals of Leicester NHS Trust and University of Leicester, Leicester, UK.
197
Royal Respiratory Research Team, Royal Liverpool University Hospital, Liverpool, UK.
198
Royal Infirmary and University of Edinburgh, UK.
199
The Royal London Hospital, Barts Health Trust, London, UK.
200
Hairmyres Hospital, Eaglesham Road, East Kilbride, G75 8RG, UK.
201
Department of Respiratory Medicine, St James's Hospital, Leeds, LS9 7TF, UK.
202
Southport and Ormskirk Hospitals NHS Trust, UK.
203
Imperial College Healthcare NHS Trust, London, UK.
204
University of Oklahoma Health Sciences Center, USA.
205
Texas A&M Health Science Center, Division of Pulmonary, Critical Care and Sleep Medicine Baylor Scott & White Health, USA.
206
Fargo VA Health Care System, Fargo, North Dakota, USA.
207
Clement J. Zablocki VA Medical Center, 5000 W. National Ave Milwaukee, WI 53295, USA; Division of Infectious Diseases, University of New Mexico School of Medicine, Raymond G. Murphy VA Medical Center, 1501 San Pedro SE Albuquerque, NM 87108, USA.
208
Division of Hospital Medicine, Cook County Hospital, Chicago, USA.
209
7th Resp. Med. Dept and Asthma Center, Athens Chest Hospital, USA.
210
Department of Medicine, Duke University Medical Center and School of Medicine, Duke Clinical Research Institute, USA.
211
Department of Pulmonary Diseases, Critical Care & Environmental Medicine, Tulane University Health Sciences Center, New Orleans, LA, USA.
212
Division of Pulmonary and Critical Care Medicine, Northwestern Memorial Hospital, Chicago, IL 60611, USA.
213
John Peter Smith Hospital, Fort Worth, TX 76104, USA.
214
Interstitial Lung Disease Programand Pulmonary Rehabilitation,SUNY Stony Brook Winthrop University Hospital, Mineola, NY 115501, USA.
215
Department of Medicine, Division of General Internal Medicine, Hospital Medicine Group, University of Colorado, USA.
216
Henry Ford Hospital, Detroit, IL, USA.
217
Pulmonary/Critical Care Medicine VA Caribbean Healthcare System, USA.
218
Tulane University, New Orleans, USA.
219
Divisions of Hospital Medicine & Pulmonary/Critical Care Medicine, South Texas Veterans Health Care System, University of Texas Health Science Center San Antonio, San Antonio, TX, USA.
220
Kaweah Delta Health Care District, Department of Emergency Medicine, Visalia, CA, USA.
221
Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
222
Department of Internal Medicine, University Teaching Hospital, Lusaka, Zambia.

Abstract

BACKGROUND:

Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP.

METHODS:

Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab. Univariate and multivariate analysis was used to evaluate risk factors.

RESULTS:

553 (14.9%) patients with CAP underwent nasal swab. Viral CAP was diagnosed in 157 (28.4%) patients. Influenza virus was isolated in 80.9% of cases. Testing frequency and viral CAP prevalence were inhomogeneous across the participating centers. Obesity (OR 1.59, 95%CI: 1.01-2.48; p = 0.043) and need for invasive mechanical ventilation (OR 1.62, 95%CI: 1.02-2.56; p = 0.040) were independently associated with viral CAP. Prevalence of empirical treatment with oseltamivir was 5.1%.

CONCLUSION:

In an international scenario, testing frequency for viruses in CAP is very low. The most common cause of viral CAP is Influenza virus. Obesity and need for invasive ventilation represent independent risk factors for viral CAP. Adherence to recommendations for treatment with oseltamivir is poor.

KEYWORDS:

Community acquired pneumonia; Influenza; Oseltamivir; Testing; Viral pneumonia; Viral swab

PMID:
30401576
DOI:
10.1016/j.ejim.2018.10.020

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center