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Obstet Gynecol Clin North Am. 2018 Dec;45(4):679-694. doi: 10.1016/j.ogc.2018.07.008. Epub 2018 Oct 25.

Sleep, Health, and Metabolism in Midlife Women and Menopause: Food for Thought.

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Department of Psychiatry, Rush University Medical Center, Rush West Campus, 2150 West Harrison Street, Room 278, Chicago, IL 60612, USA; Department of Preventive Medicine, Rush University Medical Center, 1700 West Van Buren Street, Triangle Office Building, Suite 470, Chicago, IL, USA. Electronic address:
Department of Medicine, Division of Endocrinology and Metabolism, Rush University Medical Center, 1750 West Harrison Street, Suite 604w Jelke, Chicago, IL 60612, USA.
Department of Psychiatry and Connors Center for Women's Health, Brigham and Women's Hospital, Dana Farber Cancer Institute, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.


Sleep and metabolism are essential components of health. Metabolic health depends largely on individual's lifestyle. Disturbances in sleep health, such as changes in sleep patterns that are associated with menopause/reproductive aging and chronologic aging, may have metabolic health consequences. Sleep restriction and age-related changes in sleep and circadian rhythms may influence changes in appetite and reproductive hormones, energy expenditure, and body adiposity. In this article, the authors describe how menopause-related sleep disturbance may affect eating behavior patterns, immunometabolism, immunometabolic dysfunction, and associations between sleep and metabolic outcomes.


Immunometabolism; Menopausal transition; Menopause; Metabolic health; Midlife; Sleep health

[Available on 2019-12-01]
[Indexed for MEDLINE]

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