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Trends Cell Biol. 2018 Dec;28(12):973-975. doi: 10.1016/j.tcb.2018.10.002. Epub 2018 Nov 3.

The Battle between TET Proteins and DNA Methylation for the Right Cell.

Author information

1
CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 511436, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
2
CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 511436, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: pei_duanqing@gibh.ac.cn.

Abstract

DNA methylation is an important epigenetic barrier during somatic cell reprogramming. Yet, how genome-wide methylation is reprogrammed remains largely unknown. Sardina et al. (Cell Stem Cell 2018:https://doi.org/10.1016/j.stem.2018.08.016) address this question by mapping the DNA methylomes of cells undergoing reprogramming and show that TET proteins and transcription factors cooperate to orchestrate demethylation critical to reprogramming.

KEYWORDS:

DNA methylation; TET protein; somatic cell reprogramming

PMID:
30401503
DOI:
10.1016/j.tcb.2018.10.002
[Indexed for MEDLINE]

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